Engineered T cells for cancer therapy.
Engineered T cells for cancer therapy.
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DOI:
10.1007/s00262-014-1568-1
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发表时间:
2014-09
影响因子:
5.8
通讯作者:
Porter, David L.
中科院分区:
文献类型:
--
作者:
June, Carl H.;Maus, Marcela V.;Plesa, Gabriela;Johnson, Laura A.;Zhao, Yangbing;Levine, Bruce L.;Grupp, Stephan A.;Porter, David L.
关键词:
It is now well established that the immune system can control and eliminate cancer cells. Adoptive T-cell transfer has the potential to overcome the significant limitations associated with vaccine-based strategies in patients who are often immune compromised. Application of the emerging discipline of synthetic biology to cancer, which combines elements of genetic engineering and molecular biology to create new biological structures with enhanced functionalities is the subject of this focused research review.
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