Food-derived mutagens and carcinogens.
Food-derived mutagens and carcinogens.
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DOI：
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发表时间：
1992-04
期刊：
影响因子：
11.2
通讯作者：
K. Wakabayashi;M. Nagao;H. Esumi;Takashi Sugimura
中科院分区：
文献类型：
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作者：
K. Wakabayashi;M. Nagao;H. Esumi;Takashi Sugimura
熟食中含有多种致突变的杂环胺。当在饮食中给予0.01- 0.08%时，测试的所有致突变杂环胺在啮齿动物中均具有致癌性。其中大多数会诱发肝脏和其他器官的癌症。值得注意的是，熟食中含量最多的杂环胺，2-氨基-1-甲基-6-苯基咪唑[4，5-B]吡啶，在大鼠体内可引起结肠癌和乳腺癌，在小鼠体内可引起淋巴瘤，但在这两种动物体内均未引起肝癌。2-氨基-3-甲基咪唑并[4，5-f]喹啉诱发猴肝癌。杂环胺与鸟嘌呤形成加合物可能与它们的致癌作用有关。熟食和人类尿液中杂环胺的定量表明，人类在饮食中持续接触低水平的杂环胺。这些低水平的杂环胺本身可能不足以产生人类癌症。然而，在动物中证明了DNA加合物水平和大范围剂量的杂环胺之间的线性关系。这表明，即使是非常低剂量的杂环胺形成DNA加合物，并可能涉及人类癌症的发展条件下，许多其他诱变剂致癌物，肿瘤促进剂，刺激癌症进展的因素存在。
Cooked food contains a variety of mutagenic heterocyclic amines. All the mutagenic heterocyclic amines tested were carcinogenic in rodents when given in the diet at 0.01-0.08%. Most of them induced cancer in the liver and in other organs. It is noteworthy that the most abundant heterocyclic amine in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, produced colon and mammary carcinomas in rats and lymphomas in mice but no hepatomas in either. 2-Amino-3-methylimidazo[4,5-f]quinoline induced liver cancer in monkeys. Formation of adducts with guanine by heterocyclic amines is presumably involved in their carcinogenesis. Quantification of heterocyclic amines in cooked foods and in human urine indicated that humans are continuously exposed to low levels of them in the diet. These low levels of heterocyclic amines are probably insufficient to produce human cancers by themselves. However, a linear relationship between DNA adduct levels and a wide range of doses of a heterocyclic amine was demonstrated in animals. It suggests that even very low doses of heterocyclic amines form DNA adducts and may be implicated in the development of human cancer under conditions in which many other mutagens-carcinogens, tumor promoters, and factors stimulating cancer progression exist.