Red blood cell membrane camouflaged magnetic nanoclusters for imaging-guided photothermal therapy
Red blood cell membrane camouflaged magnetic nanoclusters for imaging-guided photothermal therapy
复制标题
用于成像引导光热治疗的红细胞膜伪装磁性纳米簇。
DOI：
10.1016/j.biomaterials.2016.03.026
复制
发表时间：
2016-06-01
期刊：
影响因子：
14
通讯作者：
Sha, Xianyi
中科院分区：
文献类型：
--
作者：
Ren, Xiaoqing;Zheng, Rui;Sha, Xianyi
沿着固有的磁共振成像（MRI）的优势，氧化铁纳米材料的光热转换能力最近已经报道，并再次引起了极大的兴趣，在他们的设计之间的生物医学研究人员。然而，与其他无机纳米材料一样，高巨噬细胞摄取、短血液滞留时间和不利的生物分布严重阻碍了其在体内的应用。针对这些问题，本文提出了一种合理设计的红细胞膜包裹氧化铁磁性团簇（MNC@ RBC）。我们的数据表明，通过简单地将“超隐形”仿生涂层引入氧化铁磁性纳米团簇（MNC），MNC@ RBC保持了从MNC核心继承的成像和光热功能，同时实现了低得多的非特异性巨噬细胞摄取并显着改变了体内命运。当静脉注射到小鼠体内时，证明了MNC@ RBC具有上级的延长血液保留时间、优选的高肿瘤积聚和相对较低的肝脏生物分布，从而通过单次治疗大大增强了光热治疗功效，无需进一步的磁力操纵。我们的研究说明了MNCs和RBC的充分准备的整合，在一个单元内利用两种功能的优势，并表明铁基纳米材料在体内的应用前景广阔。(C)2016爱思唯尔有限公司版权所有。
Along with intrinsic magnetic resonance imaging (MRI) advantages, iron oxide nanomaterials capable of photothermal conversion have been reported very recently and have again raised great interest in their designs among biomedical researchers. However, like other inorganic nanomaterials, high macrophage uptake, short blood retention time and unfavorable biodistributions have strongly hampered their applications in vivo. To solve these problems, a rational design of red blood cell (RBC) membrane camouflaged iron oxide magnetic clusters (MNC@RBCs) is presented in this paper. Our data show that by simply introducing an "ultra-stealth" biomimetic coating to iron oxide magnetic nanoclusters (MNCs), MNC@RBCs maintain the imaging and photothermal functionalities inherited from MNCs cores while achieving much lower nonspecific macrophage uptake and dramatically altered fate in vivo. MNC@RBCs with superior prolonged blood retention time, preferred high tumor accumulation and relatively lowered liver biodistribution are demonstrated when injected intravenously in mice, leading to greatly enhanced photothermal therapeutic efficacy by a single treatment without further magnetic force manipulation. Our study illustrates a well prepared integration of MNCs and RBCs, exploiting advantages of both functionalities within a single unit and suggests a promising future for iron-based nanomaterials application in vivo. (C) 2016 Elsevier Ltd. All rights reserved.