Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms.
Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms.
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DOI：
10.1016/j.bbcan.2014.08.003
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发表时间：
2014-12
影响因子：
11.2
通讯作者：
Srivastava, Sanjay K.
中科院分区：
文献类型：
--
作者：
Gupta, Parul;Wright, Stephen E.;Kim, Sung-Hoon;Srivastava, Sanjay K.
流行病学证据表明，饮食中摄入十字花科蔬菜与癌症发病率之间存在强烈的负相关关系。在十字花科蔬菜的其他成分中，异硫氰酸酯（ITC）是存在的主要生物活性化学物质。异硫氰酸苯乙酯（PEITC）是十字花科蔬菜中的一种抗癌物质，具有显著的抗癌作用。已知PEITC不仅可以阻止癌发生过程的起始阶段，而且可以抑制肿瘤发生的进展。PEITC靶向多种蛋白质以抑制各种促癌机制，如细胞增殖、进展和转移。临床前证据表明，PEITC与常规抗癌剂的组合在改善总体疗效方面也非常有效。基于越来越多的证据，PEITC似乎是一种有前途的癌症治疗药物，并已在白血病和肺癌的临床试验中。这是第一次审查，提供了一个全面的分析，已知的目标和机制，沿着与PEITC作为一个未来的抗癌剂的关键评价。
The epidemiological evidence suggests a strong inverse relationship between dietary intake of cruciferous vegetables and the incidence of cancer. Among other constituents of cruciferous vegetables, isothiocyanates (ITC) are the main bioactive chemicals present. Phenethyl isothiocyanate (PEITC) is present as gluconasturtiin in many cruciferous vegetables with remarkable anti-cancer effects. PEITC is known to not only prevent the initiation phase of carcinogenesis process but also to inhibit the progression of tumorigenesis. PEITC targets multiple proteins to suppress various cancer-promoting mechanisms such as cell proliferation, progression and metastasis. Pre-clinical evidence suggests that combination of PEITC with conventional anti-cancer agents is also highly effective in improving overall efficacy. Based on accumulating evidence, PEITC appears to be a promising agent for cancer therapy and is already under clinical trials for leukemia and lung cancer. This is the first review which provides a comprehensive analysis of known targets and mechanisms along with a critical evaluation of PEITC as a future anti-cancer agent.
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