Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation
Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation
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DOI：
10.1136/thx.2004.026419
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发表时间：
2005-02-01
期刊：
影响因子：
10
通讯作者：
Sly, PD
中科院分区：
文献类型：
--
作者：
Brennan, S;Hall, GL;Sly, PD
背景：囊性纤维化（CF）肺部疾病是在儿童早期建立的，伴有反复的细菌感染和炎症。使用肺量测定法，这种早期肺损伤的影响无法测量，直到儿童6岁时，一些不可逆的肺损伤可能已经发生。用于测量婴幼儿肺功能的技术包括增加容量快速胸外按压（RVRTC）和低频强迫振荡（LFFOT）。本研究的目的是探讨炎症和感染的作用，对人口的婴儿和幼儿CF，并确定肺功能在这一人群中（LFFOT测量）是否受到早期肺部diseases.Methods：肺功能LFFOT测量24名儿童进行支气管肺泡灌洗（BAL）的27次作为年度计划的一部分，而仍然在全身麻醉。肺功能检查后，将三等份生理盐水滴入右中叶或下叶。第一份样本进行微生物检测，其余样本进行炎症标志物（细胞学、IL-8、NE、LTB 4）检测。结果：感染患儿的炎症（中性粒细胞百分比和数量）显著高于对照组（P < 0.05），而炎症反应（中性粒细胞百分比和数量）则显著高于对照组（P < 0.05）。
Background: Lung disease in cystic fibrosis (CF) is established in early childhood with recurrent bacterial infections and inflammation. Using spirometry, the effect of this early lung damage cannot be measured until a child is 6 years of age when some irreversible lung damage may already have occurred. Techniques for measurement of lung function in infants and young children include raised volume rapid thoracic compression (RVRTC) and low frequency forced oscillation (LFFOT). The aim of this study was to investigate the role of inflammation and infection on a population of infants and young children with CF and to determine whether lung function in this population ( measured by LFFOT) is affected by early lung disease.Methods: Lung function was measured by LFFOT in 24 children undergoing bronchoalveolar lavage (BAL) on 27 occasions as part of an annual programme while still under general anaesthesia. Following lung function testing, three aliquots of saline were instilled into the right middle or lower lobe. The first aliquot retrieved was processed for the detection of microbes, and the remaining aliquots were pooled to assess inflammatory markers (cytology, IL-8, NE, LTB4).Results: Inflammation ( percentage and number of neutrophils) was significantly higher in children with infections (p