Leptin receptor is involved in STAT3 activation in human colorectal adenoma
Leptin receptor is involved in STAT3 activation in human colorectal adenoma
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DOI：
10.1111/j.1349-7006.2010.01803.x
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发表时间：
2011-02
期刊：
影响因子：
5.7
通讯作者：
T. Uchiyama;Hirokazu Takahashi;Michiko Sugiyama;E. Sakai;Hiroki Endo;K. Hosono;K. Yoneda;M. Yoneda;M. Inamori;Y. Nagashima;Y. Inayama;K. Wada;A. Nakajima
中科院分区：
文献类型：
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作者：
T. Uchiyama;Hirokazu Takahashi;Michiko Sugiyama;E. Sakai;Hiroki Endo;K. Hosono;K. Yoneda;M. Yoneda;M. Inamori;Y. Nagashima;Y. Inayama;K. Wada;A. Nakajima
瘦素在结直肠肿瘤中的可能作用已在之前的研究中进行过研究。然而，迄今为止，结论仍在争论中。因此，我们研究了结直肠腺瘤患者的血清瘦素水平。此外，在从人类结直肠腺瘤患者采集的活检标本中研究了瘦素受体的表达以及瘦素受体介导的信号通路。结直肠腺瘤患者和对照受试者之间的平均血清瘦素水平没有观察到显着差异；然而，在结直肠腺瘤组织中观察到瘦素受体的表达和激活增加，如 Tyr 1141 磷酸化等结果所示。此外，与非腺瘤组织相比，在结直肠腺瘤中观察到由瘦素受体介导的 JAK/STAT 信号通路的激活以及下游靶分子转录调控的增加。这些结果表明 STAT3 介导的瘦素受体信号通路可能在人类结直肠腺瘤中被激活。 （《癌症科学》2011 年；102：367–372）
The possible role of leptin in colorectal tumors has been investigated in previous studies; however, to date, the conclusions remain under debate. Therefore, we investigated the serum leptin levels in colorectal adenoma patients. In addition, expression of the leptin receptor, and the leptin receptor‐mediated signaling pathways were investigated in biopsy specimens collected from human patients with colorectal adenoma. No significant difference in the mean serum leptin level was observed between the colorectal adenoma patients and the control subjects; however, increased expression and activation of the leptin receptor, as indicated by findings such as the phosphorylation of Tyr 1141, was observed in the colorectal adenoma tissues. In addition, activation of the JAK/STAT signaling pathway mediated by the leptin receptor and increased transcriptional regulation of downstream target molecules were observed in colorectal adenomas compared with the non‐adenoma tissues. These results indicate STAT3‐mediated leptin receptor signaling pathways may be activated in human colorectal adenomas. (Cancer Sci 2011; 102: 367–372)