Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus 1 in the absence of virion host shutoff.
Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus 1 in the absence of virion host shutoff.
复制标题
在没有病毒颗粒宿主关闭的情况下，角膜复制是单纯疱疹病毒 1 毒力的独立于干扰素反应的瓶颈。
DOI：
10.1128/jvi.00761-12
复制
发表时间：
2012
影响因子：
5.4
通讯作者：
Leib,DavidA
中科院分区：
文献类型：
--
作者：
Pasieka,TracyJo;Menachery,VineetD;Rosato,PamelaC;Leib,DavidA
Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR−/−) mice, Δvhs remains highly attenuated via corneal infection but is fully virulent via intracranial infection. The data demonstrate that the interferon-independent inherent replication defect of Δvhs has a significant impact upon peripheral replication and neuroinvasion.
