Medication Treatment Complexity and Adherence in Children with CKD
Medication Treatment Complexity and Adherence in Children with CKD
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DOI：
10.2215/cjn.05750513
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发表时间：
2014-02-07
影响因子：
9.8
通讯作者：
Furth, Susan L.
中科院分区：
文献类型：
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作者：
Blydt-Hansen, Tom D.;Pierce, Christopher B.;Furth, Susan L.
背景和目的儿童CKD管理的复杂性随着合并症的数量增加而增加。本研究通过评估CKD分期和诊断的流行药物使用及其与临床或社会人口学因素的相关性，评估了儿童CKD合并症的患病率和多种合并症共同存在的频率。设计、设置、参与者和测量在儿童慢性肾脏病研究的这一横断面分析中，通过CKD阶段、诊断、年龄、种族、民族、收入和CKD持续时间检查按适应症分组的研究进入时的药物使用。对药物使用和聚集的多变量校正预测因子进行了研究。结果558名合格的参与者中位年龄为11岁，中位GFR为44 ml/min/1.73 m2; 62%的参与者为男性，78%患有非肾小球性肾病。CKD合并症的治疗药物数量随着CKD分期的进展而增加（IV期是II期的2.5倍; P
Background and objectives The complexity of CKD management in children is increased by the number of comorbid conditions. This study assessed the prevalence of comorbidities in pediatric CKD and the frequency with which multiple comorbidities present together by assessing prevalent medication use by CKD stage and diagnosis and their association with clinical or sociodemographic factors. The association between number and frequency of dosing of medications prescribed and self-report of nonadherence was also assessed.Design, setting, participants, & measurements In this cross-sectional analysis of the Chronic Kidney Disease in Children study, medication use at study entry grouped by indication was examined by CKD stage, diagnosis, age, race, ethnicity, income, and CKD duration. Multivariate adjusted predictors of medication use and clustering were examined. Nonadherence was assessed by self-report of missed medications in the past 7 days.Results The 558 eligible participants had a median age of 11 years and median GFR of 44 ml/min per 1.73 m(2); 62% of participants were male and 78% had nonglomerular kidney disease. The number of medications for treatment of CKD comorbidities increased with advanced CKD stage (2.5-fold for stages IV versus II; P