Cardiac Amyloidosis Associated with Apolipoprotein A-IV Deposition Diagnosed by Mass Spectrometry-Based Proteomic Analysis
Cardiac Amyloidosis Associated with Apolipoprotein A-IV Deposition Diagnosed by Mass Spectrometry-Based Proteomic Analysis
复制标题
通过基于质谱的蛋白质组学分析诊断与载脂蛋白 A-IV 沉积相关的心脏淀粉样变性
DOI：
10.12890/2019_001237
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发表时间：
2019
影响因子：
--
通讯作者：
I. Tavares
中科院分区：
文献类型：
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作者：
Elisabete Martins;J. Urbano;S. Leite;Adriana Pinto;Raquel Garcia;Rui Bergantim;P. Rodrigues;P. Costa;Hugo Osório;I. Tavares
淀粉样变性是一组以细胞外不溶性蛋白聚集体沉积为特征的疾病。临床治疗取决于淀粉样蛋白前体和根本原因的准确识别。我们描述了一个罕见的载脂蛋白a - iv心脏淀粉样变性病例，其诊断需要基于质谱的蛋白质组学分析。学习要点能够运用影像学方法、分析结果和组织分析对心脏淀粉样变亚型进行鉴别诊断。认识到基于质谱（MS）的蛋白质组学分析的附加价值。
Amyloidosis is a group of disorders characterised by the accumulation of extracellular deposits of insoluble protein aggregates. Clinical management depends on the accurate identification of the amyloid precursor and underlying cause. We describe a rare case of apolipoprotein A-IV cardiac amyloidosis, the diagnosis of which required mass spectrometry-based proteomic analysis. LEARNING POINTS To be able to perform the differential diagnosis of cardiac amyloidosis subtypes using imaging methods, analytical results and tissue analysis. To recognise the added value of mass spectrometry (MS)-based proteomic analysis.