High frame rate retrospectively triggered Cine MRI for assessment of murine diastolic function
High frame rate retrospectively triggered Cine MRI for assessment of murine diastolic function
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DOI：
10.1002/mrm.24287
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发表时间：
2013-03-01
影响因子：
3.3
通讯作者：
Strijkers, Gustav J.
中科院分区：
文献类型：
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作者：
Coolen, Bram F.;Abdurrachim, Desiree;Strijkers, Gustav J.
为了评估小鼠左心室（LV）舒张功能，需要高帧率（每心动周期60帧）。对于传统的心电图触发的Cine MRI，帧率与脉冲重复时间（TR）成反比。然而，由于梯度硬件、空间分辨率和信噪比的限制，不能随意降低TR来提高帧率。为了克服这些与心电图触发的Cine MRI相关的局限性，在本文中，我们介绍了一种回顾性触发的Cine MRI方案，该方案能够产生高分辨率的高帧率的小鼠心脏Cine MRI，以解决左心室舒张功能。模拟研究了MRI序列参数和k空间填充轨迹对每个心动周期所需帧数的影响。优化的方案在体内应用，并与心电图触发的Cine进行比较，后者只能通过几个交错采集来实现高帧率。回顾性高帧率电影MRI证明优于交错心电图触发方案。在25分钟内获得了帧率高达80帧/心跳周期的高空间分辨率电影。左心室充盈率曲线的分析可以准确地确定早期和晚期充盈率，并显示与非糖尿病小鼠相比，糖尿病小鼠左心室舒张功能的细微损害。《理性医学杂志》，2013。(c) 2012 Wiley期刊有限公司
To assess left ventricular (LV) diastolic function in mice with Cine MRI, a high frame rate (>60 frames per cardiac cycle) is required. For conventional electrocardiography-triggered Cine MRI, the frame rate is inversely proportional to the pulse repetition time (TR). However, TR cannot be lowered at will to increase the frame rate because of gradient hardware, spatial resolution, and signal-to-noise limitations. To overcome these limitations associated with electrocardiography-triggered Cine MRI, in this paper, we introduce a retrospectively triggered Cine MRI protocol capable of producing high-resolution high frame rate Cine MRI of the mouse heart for addressing left ventricular diastolic function. Simulations were performed to investigate the influence of MRI sequence parameters and the k-space filling trajectory in relation to the desired number of frames per cardiac cycle. An optimized protocol was applied in vivo and compared with electrocardiography-triggered Cine for which a high-frame rate could only be achieved by several interleaved acquisitions. Retrospective high frame rate Cine MRI proved superior to the interleaved electrocardiography-triggered protocols. High spatial-resolution Cine movies with frames rates up to 80 frames per cardiac cycle were obtained in 25 min. Analysis of left ventricular filling rate curves allowed accurate determination of early and late filling rates and revealed subtle impairments in left ventricular diastolic function of diabetic mice in comparison with nondiabetic mice. Magn Reson Med, 2013. (c) 2012 Wiley Periodicals, Inc.