Burden of Tracheal, Bronchus, and Lung Cancer and Its Attributable Risk Factors in 204 Countries and Territories, 1990 to 2019
Burden of Tracheal, Bronchus, and Lung Cancer and Its Attributable Risk Factors in 204 Countries and Territories, 1990 to 2019
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DOI：
10.1016/j.jtho.2021.03.030
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发表时间：
2021-05-22
影响因子：
20.4
通讯作者：
Kolahi, Ali-Asghar
中科院分区：
文献类型：
--
作者：
Safiri, Saeid;Sohrabi, Mohammad-Reza;Kolahi, Ali-Asghar
简介：了解全球气管癌、支气管癌和肺癌 (TBL) 的年发病率、死亡率和伤残调整生命年 (DALY) 的趋势对于合理分配用于预防、临床实践改进和研究的资源非常重要。本研究的目的是按年龄、性别和社会人口统计指数确定 1990 年至 2019 年 204 个国家和地区 TBL 癌症的全球、区域和国家负担。方法：通过各种数据输入进行估计，包括以下内容：癌症登记（n（地点年）= 5318）、生命登记（n（地点年）= 22,553）、生命登记样本（n（地点年）= 825），以及口头尸检（n（地点年）= 516）。对年发病率、死亡率和 DALY 进行了估计，并以每 100,000 人的计数和年龄标准化率表示。结果：有 230 万（95% 不确定区间 [UI]：2.1-2.5）TBL 癌症发病病例，年龄标准化年发病率为 27.7（95% UI：25.3-30），下降了 2.6%（95% UI：-12.4） 1990 年至 2019 年间，TBL 癌症导致全球 200 万人（95% UI：1.9-2.2）死亡，年龄标准化死亡率为 25.2（95% UI：23.2-27），1990 年至 2019 年间下降了 7.8%（95% UI：-15.9 至 0.2）。此外，TBL 占全球有 4590 万（95% UI：42.3-49.3）DALY，年龄标准化率为每 10 万人 551.6（95% UI：509-593.1）DALY。从 1990 年到 2019 年，标准化伤残调整生命年率下降了 16.2%（95% UI：-24 至-8.2）。格陵兰岛（77.7 [95% UI：64.4-90.6]）、摩纳哥（75.6 [95% UI：61.4-90.8]）和黑山（56.7 [95% UI：61.4-90.8]）。 46.5-68.9]）具有三个最高的年龄标准化年发病率。上述三个国家的 TBL 癌症年龄标准化死亡率和 DALY 率也是最高的三个国家。 1990年至2019年间，洪都拉斯（68% [95% UI: 14.5-137.7]）、佛得角（62.2% [95% UI: 24.1-101.3]）和摩纳哥（58.2% [95% UI: 19.2-109.7]）的TBL癌症年龄标准化年发病率增幅最大。洪都拉斯（67.1% [95% UI: 14.7-133.1]）、佛得角（64.4% [95% UI: 25-103.4]）和莫桑比克（49.9% [95% UI: 7.9 -101.3]）的TBL癌症年龄标准化死亡率增幅最大。男性的年龄标准化年发病率和死亡率高于女性，并且随着人口老龄化而增加。年龄标准化伤残调整生命年率与相应国家的社会人口指数之间存在非线性但总体正相关关系。在全球范围内，吸烟 (62.4%)、环境颗粒物 (15.3%) 和高空腹血糖 (9.9%) 是 2019 年男女 TBL 癌症所致 DALY 百分比最高的前三位。 结论：这项研究发现，全球负担有所下降，但有些国家有所增加。这些结果对于确定 TBL 癌症预防和治疗的优先顺序至关重要，并且对政策制定者、政府官员、临床医生和研究人员有益。 (C) 2021 年国际肺癌研究协会。由爱思唯尔公司出版。保留所有权利。
Introduction: Understanding trends in the annual incidence, mortality, and disability-adjusted life-years (DALYs) for tracheal, bronchus, and lung (TBL) cancer globally is important to enable appropriate targeting of resources for prevention, clinical practice improvement, and research. The aim of this study was to determine the global, regional, and national burdens of TBL cancer in 204 countries and territories from 1990 to 2019 by age, sex, and sociodemographic index.Methods: Estimates were produced through various data inputs including the following: cancer registries (n(site-years) = 5318), vital registration (n(site-years) = 22,553), vital registration-sample (n(site-years) = 825), and verbal autopsies (n(site-years) = 516). Annual incidence, mortality, and DALYs were estimated and presented as counts and age standardized rates per 100,000 population.Results: There were 2.3 million (95% uncertainty interval [UI]: 2.1-2.5) incident cases of TBL cancer, with an age standardized annual incidence rate of 27.7 (95% UI: 25.3- 30), which decreased by 2.6% (95% UI:-12.4 to 6.5) between 1990 and 2019. TBL cancer was responsible for 2 million (95% UI: 1.9-2.2) deaths globally with an age standardized death rate of 25.2 (95% UI: 23.2-27), a decrease of 7.8% (95% UI:-15.9 to 0.2) between 1990 and 2019. Moreover, TBL accounted for 45.9 million (95% UI: 42.3-49.3) DALYs at the global level, with an age standardized rate of 551.6 (95% UI: 509-593.1) DALYs per 100,000 population. The standardized DALY rate declined by 16.2% (95% UI:-24 to-8.2) from 1990 to 2019. Greenland (77.7 [95% UI: 64.4-90.6]), Monaco (75.6 [95% UI: 61.4-90.8]), and Montenegro (56.7 [95% UI: 46.5-68.9]) had the three highest age-standardized annual incidence rates. The aforementioned three countries also had the three highest age-standardized death and DALY rates of TBL cancer. Honduras (68% [95% UI: 14.5-137.7]), Cabo Verde (62.2% [95% UI: 24.1-101.3]), and Monaco (58.2% [95% UI: 19.2-109.7]) had the largest increase in age-standardized annual incidence rates for TBL cancer during 1990 to 2019. The largest increases were found in age-standardized death rates of TBL cancer in Honduras (67.1% [95% UI: 14.7-133.1]), Cabo Verde (64.4% [95% UI: 25-103.4]), and Mozambique (49.9% [95% UI: 7.9 -101.3]). Age-standardized annual incidence and death rates were higher in male than female individuals and increased with population aging. There were nonlinear but generally positive associations between age-standardized DALY rates with corresponding sociodemographic index of countries. Globally, smoking (62.4%), ambient particulate matter (15.3%), and high fasting plasma glucose (9.9%) had the top three highest percent of attributable DALYs owing to TBL cancer in 2019 for both sexes.Conclusions: This study found a decline in burden globally but with some countries having an increase. These results are crucial to set priorities for prevention and treatment of TBL cancer and would be beneficial for policymakers, government officials, clinicians, and researchers. (C) 2021 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.