The conformational and subcellular compartmental dance of plant NLRs during viral recognition and defense signaling.
The conformational and subcellular compartmental dance of plant NLRs during viral recognition and defense signaling.
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DOI：
10.1016/j.mib.2014.05.003
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发表时间：
2014-08
影响因子：
5.4
通讯作者：
Dinesh-Kumar SP
中科院分区：
文献类型：
--
作者：
Padmanabhan MS;Dinesh-Kumar SP
针对病毒的植物先天免疫应答利用细胞内核苷酸结合结构域富含亮氨酸重复序列（NLR）类受体。NLR识别称为激发子的不同病毒蛋白，并启动不同的信号传导过程，诱导受感染细胞中的程序性细胞死亡（PCD）并限制病毒传播。本文综述了近年来植物近红外光谱检测病毒的研究进展。我们描述了一些物理和功能的相互作用，这些NLR进行。我们阐述了在自我调节和激活功能的NLR的分子内和同型关联。一些病毒NLR的核作用进行了讨论，以及新出现的重要性的RNAi途径在调节NLR家族。
Plant innate immune response against viruses utilizes intracellular Nucleotide Binding domain Leucine Rich Repeat (NLR) class of receptors. NLRs recognize different viral proteins termed elicitors and initiate diverse signaling processes that induce programmed cell death (PCD) in infected cells and restrict virus spread. In this review we describe the recent advances made in the study of plant NLRs that detect viruses. We describe some of the physical and functional interactions these NLRs undertake. We elaborate on the intra-molecular and homotypic association of NLRs that function in self-regulation and activation. Nuclear role for some viral NLRs is discussed as well as the emerging importance of the RNAi pathway in regulating the NLR family.