Highly efficient asymmetric synthesis of 3-indolyl(hydroxy)acetates via Friedel-Crafts alkylation of indoles.

Highly efficient asymmetric synthesis of 3-indolyl(hydroxy)acetates via Friedel-Crafts alkylation of indoles.
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DOI：
10.1021/jo901425z
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发表时间：
2009-08
期刊：
The Journal of organic chemistry
影响因子：
--
通讯作者：
Y. Hui;Qi Zhang;Jun Jiang;Lili Lin;Xiaohua Liu;Xiaoming Feng
Y. Hui;Qi Zhang;Jun Jiang;Lili Lin;Xiaohua Liu;Xiaoming Feng
中科院分区：
其他
文献类型：
--
作者：
Y. Hui;Qi Zhang;Jun Jiang;Lili Lin;Xiaohua Liu;Xiaoming Feng

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研究了手性N，N'-二氧化硅- sc （III）配合物催化吲哚的Friedel-Crafts烷基化反应。相应的3-吲哚（羟基）乙酸酯化合物产率高，对映选择性高（高达95% ee）。
An efficient enantioselective Friedel-Crafts alkylation of indoles to ethyl glyoxylate catalyzed by chiral N,N'-dioxide-Sc(III) complex was developed. The corresponding 3-indolyl(hydroxy)acetates compounds were afforded in good yields with high enantioselectivities (up to 95% ee).