Neural mechanisms relevant to the design of an auditory prosthesis. Location and electrical characteristics.
Neural mechanisms relevant to the design of an auditory prosthesis. Location and electrical characteristics.
复制标题
与听觉假体设计相关的神经机制。
DOI：
--
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
F. Spelman
中科院分区：
文献类型：
--
作者：
B. Clopton;F. Spelman
人工耳蜗设计的电刺激第八神经纤维在聋人进行了研究，在急性豚鼠制剂。假体由两对铂铱电极组成，通过圆窗插入鼓阶。比较了不同电流通路的电阻抗及其在中枢听觉系统中诱发神经反应的有效性。假设集中的神经元，结果表明，神经兴奋的网站位于鼓阶之外。神经兴奋的频率响应特性与通过组织到刺激部位的电流的电阻性传播一致。神经膜的特性类似于那些以前在非哺乳动物神经研究似乎占的响应启动。
A cochlear prosthesis designed to electrically stimulate eighth nerve fibers in deaf subjects was studied in acute guinea pig preparations. The prosthesis, which consisted of two pairs of platinum-iridium electrodes, was inserted into the scala tympani through the round window. The electrical impedances of different current paths and their effectiveness in evoking neural responses in the central auditory system are compared. Assuming lumped neural elements, the results indicate that the sites of neural excitation lie outside the scala tympani. Frequency-response characteristics of neural excitation are in agreement with resistive spread of current through tissue to the site of stimulation. Neural membrane characteristics similar to those previously studied in nonmammalian nerves seem to account for the response initiation.