Unrecognized leukemia cutis.
Unrecognized leukemia cutis.
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未被识别的皮肤白血病。
DOI：
10.1097/00007611-198705000-00030
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发表时间：
1987
影响因子：
1.1
通讯作者：
Greco,FA
中科院分区：
文献类型：
--
作者：
Hainsworth,JD;Greco,FA
在一位76岁有乳腺癌病史的女性患者中，从活检结果来看，弥漫性红斑结节性皮疹被认为是转移性乳腺癌所致。外周血和骨髓未见异常。患者仅接受他莫昔芬治疗假定复发性乳腺癌。在接下来的九个月里，皮肤病变完全消退，但随后出现了急性粒单核细胞白血病。骨髓中的白血病原始细胞与之前皮肤活检中的恶性细胞相同。正确识别肿瘤性皮肤浸润变得越来越重要，因为许多类型的肿瘤都有有效的治疗方法。如果光学显微镜下的外观不确定，则应考虑细胞化学或免疫组织化学染色和/或电子显微镜检查。
In a 76-year-old woman with a history of breast cancer, a diffuse erythematous maculonodular skin eruption was thought from biopsy results to be due to metastatic breast carcinoma. Peripheral blood and bone marrow showed no abnormalities. The patient received only tamoxifen for presumed recurrent breast carcinoma. The skin lesions totally resolved over the next nine months, but acute myelomonocytic leukemia subsequently developed. The leukemic blasts in the bone marrow were identical to the malignant cells in the previous skin biopsies. Correct identification of neoplastic skin infiltrations has become increasingly important, since effective therapy is available for many types of neoplasms. Cytochemical or immunohistochemical staining and/or electron microscopy should be considered if the appearance on light microscopy is inconclusive.