Polyomavirus infection in a free-ranging California sea lion (Zalophus californianus) with intestinal T-cell lymphoma
Polyomavirus infection in a free-ranging California sea lion (Zalophus californianus) with intestinal T-cell lymphoma
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DOI：
10.1177/104063871002200422
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发表时间：
2010-07-01
影响因子：
1.5
通讯作者：
Nollens, Hendrik H.
中科院分区：
文献类型：
--
作者：
Colegrove, Kathleen M.;Wellehan, James F. X., Jr.;Nollens, Hendrik H.
一只搁浅在加州中部的成年雌性加州海狮（Zalophus californianus）在大体尸检中被发现有一个小的舌息肉样肿块。组织学上，肿块与纤维乳头状瘤一致，并且在肿块内衬有小动脉的内皮细胞内发现核内包涵体。电子显微镜显示内皮细胞核内包涵体中有 40 nm 的病毒颗粒。使用滚环扩增获得部分病毒基因组序列。序列分析鉴定该病毒为一种新型多瘤病毒，暂命名为加州海狮多瘤病毒1型。此外，肉眼检查发现，该海狮小肠严重增厚，肾脏肿胀苍白。组织学诊断为严重肾淀粉样变性伴慢性间质性肾炎，以及通过免疫表型和分子克隆证实的T细胞肠淋巴瘤。多瘤病毒感染与这只海狮的其他疾病过程之间的关系（如果有的话）尚不清楚，但据认为多瘤病毒不太可能诱发淋巴瘤。
An adult female California sea lion (Zalophus californianus) that stranded in central California was found to have a small glossal polypoid mass on gross necropsy. Histologically, the mass was consistent with a fibropapilloma, and intranuclear inclusions were found within endothelial cells lining small arterioles within the mass. Electron microscopy revealed 40-nm virions within endothelial intranuclear inclusions. Rolling circle amplification was used to obtain a partial viral genomic sequence. Sequence analysis identified the virus as a novel polyomavirus, tentatively named California sea lion polyomavirus 1. In addition, the sea lion had a severely thickened small intestine and swollen pale kidneys on gross examination. Severe renal amyloidosis with chronic interstitial nephritis was diagnosed histologically as well as T-cell intestinal lymphoma, which was confirmed via immunophenotyping and molecular clonality. The relationship, if any, between polyomavirus infection and the other disease processes in this sea lion is not known, but it is considered unlikely that the polyomavirus induced the lymphoma.