Vibration-induced inhibition of vascular smooth muscle contraction.
Vibration-induced inhibition of vascular smooth muscle contraction.
复制标题
振动引起的血管平滑肌收缩抑制。
DOI：
10.1159/000158037
复制
发表时间：
1975
期刊：
影响因子：
--
通讯作者：
R. Sivertsson
中科院分区：
文献类型：
--
作者：
B. Ljung;R. Sivertsson
已知血管平滑肌在生理和病理生理条件下以及在不同的职业和环境情况下暴露于振荡应变。平滑肌振动的影响似乎在很大程度上是未知的。在目前的实验中，对大鼠门静脉和兔胸主动脉的离体标本，发现正弦长度的强制变化引起主动力的迅速减少，其程度取决于振幅（组织长度的1-10%，峰到峰，即大约正负50-500 μ m）和振动频率（1-400 Hz）以及主动力和被动力的主要水平。振动仅引起血管平滑肌被动力的小的和不一致的减少。这些结果与振动通过引起肌动蛋白-肌球蛋白交联的分离率增加而对收缩过程施加直接作用的假设是一致的。有人建议，在体内，振动可能会影响局部的情况下，湍流的血流狭窄后扩张和动静脉吻合的管道动脉的直径。可能的是，即使是正常的脉压振荡有时也可能倾向于抑制这些动脉中的平滑肌活动，从而影响它们的直径。
Vascular smooth muscle is known to be exposed to an oscillating strain under physiological and patho-physiological conditions as well as in different occupational and environmental situations. The effect of vibrations of smooth muscle seems to be largly unknown. In the present experiments on isolated preparations of the rat portal vein and the rabbit thoracic aorta, imposed sinusoidal changes in length were found to cause prompt reduction in active force, the extent of which was dependent on amplitude (1-10% of tissue length, peak to peak, i.e. approximately plus or minus 50-500 mum) and frequency of vibration (1-400 Hz) as well as on the prevailing level of active and passive forces. Vibration caused only small and inconsistant reductions of passive force of vascular smooth muscle. The results are in accordance with the hypothesis that vibrations exert a direct action on the contractile process by causing an increased rate of detachment of actin-myosin cross-links. It is suggested that, in vivo, vibrations may affect the diameter of conduit arteries locally in the case of turbulent blood flow as seen in post-stenotic dilation and arterio-venous anastomosis. Possibly, even the normal pulse pressure oscillations may sometimes tend to inhibit the smooth muscle activity in such arteries and thereby influence their diameters.