4.0 T water proton T1 relaxation times in normal human brain and during acute ethanol intoxication
4.0 T water proton T1 relaxation times in normal human brain and during acute ethanol intoxication
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DOI：
10.1111/j.1530-0277.2000.tb02062.x
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发表时间：
2000-06-01
影响因子：
3.2
通讯作者：
Volkow, ND
中科院分区：
文献类型：
--
作者：
Rooney, WD;Lee, JH;Volkow, ND
背景资料：据报道，急性乙醇中毒降低脑水质子磁共振T-1值，这种效应被解释为表明在这种情况下大脑脱水。由于水大分子相互作用在很大程度上决定了组织水T-1，脑水质子T-1值降低的另一种可能的解释是水和脑大分子之间的相互作用被乙醇改变。用4.0T磁共振成像仪测定酒精中毒前、中、后脑水质子T-1相对时间结果：MRI测量的T-1弛豫时间具有高度的可重复性。平均成对乙醇诱导的T-1差异为-0.004 +/- 0.007秒白色结构的平均值±标准差为0.010 ± 0.015秒，内部灰质结构的平均值±标准差为0.010 ± 0.015秒，两者均不显著。这种合理敏感的测量不支持组织含水量或水大分子相互作用显著改变的观点在其他健康受试者的急性酒精中毒过程中大脑中。
Background: It has been reported that acute ethanol intoxication decreases the brain water proton magnetic resonance T-1 values, an effect that has been interpreted to indicate brain dehydration during this condition. Because water macromolecular interactions largely determine tissue water T-1, another possible explanation for reduced brain water proton T-1 values is that the interaction between water and brain macromolecules is altered by ethanol.Methods: A 4.0 T magnetic resonance imaging (MRI) instrument was used to measure brain water proton T-1 relavation times before, during, and after ethanol intoxication (dose, 0.75 mg/kg) in healthy centrols.Results: The T-1 relaxation times as assessed with MRI were highly reproducible. The mean, paired ethanol-induced differences in T-1 were -0.004 +/- 0.007 sec (mean +/- standard deviation) for white matter and 0.010 +/- 0.015 sec for internal gray matter structures, neither of which was significant.Conclusions: This reasonably sensitive measurement does not support the view that tissue water content or water macromolecule interactions are significantly altered in the brain during acute alcohol intoxication in otherwise healthy subjects.