Effect of coffee consumption on all-cause and total cancer mortality: findings from the JACC study
Effect of coffee consumption on all-cause and total cancer mortality: findings from the JACC study
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DOI：
10.1007/s10654-011-9548-7
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发表时间：
2011-04-01
影响因子：
13.6
通讯作者：
Iso, Hiroyasu
中科院分区：
文献类型：
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作者：
Tamakoshi, Akiko;Lin, Yingsong;Iso, Hiroyasu
众所周知，喝咖啡与各种健康状况有关。最近，各种队列研究表明其抗氧化作用与全因或癌症死亡率有关。然而，只有一项小型亚洲队列研究评估了这种关联。因此，我们试图通过在日本进行一项大规模队列研究来评估咖啡与全因和总癌症死亡率之间的关系。共有97,753名年龄在40-79岁之间的日本男性和女性接受了为期16年的跟踪调查。根据比例风险回归模型计算出与咖啡摄入相关的全因和总癌症死亡率的风险比和95%置信区间。随访期间共有19,532人死亡；其中34.8%死于癌症。男性和女性的全因死亡风险随着咖啡消费量的增加而降低，与女性消费量第二高的水平相比，咖啡消费量最高的水平（每千日元4杯/天）的风险升高，尽管在这一水平上评估的受试者人数很少。在男性中，咖啡摄入量与癌症总死亡率之间没有关联，而在女性中则存在微弱的负相关。目前在日本人群中进行的队列研究表明，咖啡对男性和女性的全因死亡率都有有益的影响。此外，研究结果表明，喝咖啡可能与癌症总死亡率的增加无关。
Coffee consumption is known to be related to various health conditions. Recently, its antioxidant effects have been suggested to be associated with all-cause or cancer mortality by various cohort studies. However, there has been only one small Asian cohort study that has assessed this association. Thus, we tried to assess the association of coffee with all-cause and total cancer mortality by conducting a large-scale cohort study in Japan. A total of 97,753 Japanese men and women aged 40-79 years were followed for 16 years. Hazard ratios and 95% confidence intervals of all-cause and total cancer mortality in relation to coffee consumption were calculated from proportional-hazards regression models. A total of 19,532 deaths occurred during the follow-up period; 34.8% of these deaths were caused by cancer. The all-cause mortality risk decreased with increasing coffee consumption in both men and women, with a risk elevation at the highest coffee consumption level (a parts per thousand yen4 cups/day) compared with the 2nd highest consumption level in women, although the number of subjects evaluated at this level was small. No association was found between coffee consumption and total cancer mortality among men, whereas a weak inverse association was found among women. The present cohort study among the Japanese population suggested that there are beneficial effects of coffee on all-cause mortality among both men and women. Furthermore, the results showed that coffee consumption might not be associated with an increased risk of total cancer mortality.