Temporal Order Memory Assessed during Spatiotemporal Navigation As a Behavioral Cognitive Marker for Differential Alzheimer's Disease Diagnosis
Temporal Order Memory Assessed during Spatiotemporal Navigation As a Behavioral Cognitive Marker for Differential Alzheimer's Disease Diagnosis
复制标题
DOI：
10.1523/jneurosci.4556-11.2012
复制
发表时间：
2012-02-08
影响因子：
5.3
通讯作者：
Rondi-Reig, Laure
中科院分区：
文献类型：
--
作者：
Bellassen, Virginie;Igloi, Kinga;Rondi-Reig, Laure
情景记忆障碍是阿尔茨海默病早期诊断的标志。大多数用于诊断阿尔茨海默病的实际测试并不评估情景记忆的时空特性，并导致假阳性或假阴性诊断。我们使用了一种新开发的，非语言导航测试人类，基于客观的实验测试的时空经验，区分阿尔茨海默病在轻度阶段（N = 16例），额颞叶变性（N = 11例）和正常老化（N = 24例）。比较导航参数和标准神经心理学测试，与额颞叶变性和正常衰老相比，时间顺序记忆似乎对轻度阿尔茨海默病诊断具有最高的预测能力。这个测试与经典的神经心理学测试也是不冗余的。总之，我们的研究结果表明，在空间导航任务中测试的时间顺序记忆可能提供了阿尔茨海默病的选择性行为标记。
Episodic memory impairment is a hallmark for early diagnosis of Alzheimer's disease. Most actual tests used to diagnose Alzheimer's disease do not assess the spatiotemporal properties of episodic memory and lead to false-positive or -negative diagnosis. We used a newly developed, nonverbal navigation test for Human, based on the objective experimental testing of a spatiotemporal experience, to differentially Alzheimer's disease at the mild stage (N = 16 patients) from frontotemporal lobar degeneration (N = 11 patients) and normal aging (N = 24 subjects). Comparing navigation parameters and standard neuropsychological tests, temporal order memory appeared to have the highest predictive power for mild Alzheimer's disease diagnosis versus frontotemporal lobar degeneration and normal aging. This test was also nonredundant with classical neuropsychological tests. As a conclusion, our results suggest that temporal order memory tested in a spatial navigation task may provide a selective behavioral marker of Alzheimer's disease.