Effects of intensity of acute-resistance exercise on rates of protein synthesis in moderately diabetic rats.
Effects of intensity of acute-resistance exercise on rates of protein synthesis in moderately diabetic rats.
复制标题
急性抗阻运动强度对中度糖尿病大鼠蛋白质合成率的影响。
DOI：
10.1152/jappl.1998.85.6.2291
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Jefferson,LS
中科院分区：
文献类型：
--
作者：
Farrell,PA;Fedele,MJ;Vary,TC;Kimball,SR;Jefferson,LS
These studies determined whether increases in rates of protein synthesis observed in skeletal muscle after moderate or severe acute-resistance exercise were blunted by insulinopenia. Rats (n= 6–9 per group) were made insulin deficient by partial pancreatectomy or remained nondiabetic. Groups either remained sedentary or performed acute-resistance exercise 16 h before rates of protein synthesis were measured in vivo. Exercise required 50 repetitions of standing on the hindlimbs with either 0.6 g backpack wt/g body wt (moderate exercise) or 1.0 g backpack wt/g body wt (severe exercise). Insulin-deficient rats had a mean blood glucose concentration >15 mM and reduced insulin concentrations in the plasma. Rates of protein synthesis in gastrocnemius muscle were not different in all sedentary groups. The moderate-exercised nondiabetic group (192 ± 12 nmol phenylalanine incorporated ⋅ g muscle−1⋅ h−1) and moderate-exercised diabetic group (215 ± 18) had significantly (P< 0.05, ANOVA) higher rates of protein synthesis than did respective sedentary groups. In contrast, diabetic rats that performed severe-resistance exercise had rates of protein synthesis (176 ± 12) that were not different (P> 0.05) from diabetic sedentary rats (170 ± 9), whereas nondiabetic rats that performed severe exercise had higher (212 ± 24) rates compared with nondiabetic sedentary rats (178 ± 10)P< 0.05. The present data in combination with previous studies [J. D. Fluckey, T. C. Vary, L. S. Jefferson, and P. A. Farrell.Am. J. Physiol. 270 (Endocrinol. Metab.33): E313–E319, 1996] show that the amount of insulin required for an in vivo permissive effect of insulin on rates of protein synthesis can be quite low after moderate-intensity resistance exercise. However, severe exercise in combination with low insulin concentrations can ablate an anabolic response.
