The safety of the hepatitis B vaccine.
The safety of the hepatitis B vaccine.
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乙型肝炎疫苗的安全性。
DOI：
10.1001/jama.1987.03390030045013
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
A. Meric
中科院分区：
文献类型：
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作者：
A. Meric
致编辑。我饶有兴趣地阅读了题为“乙肝疫苗的安全性”的文章。作者令人信服地证明了获得性免疫缺陷综合征（AIDS）病毒传染性的失活和可沉积逆转录酶活性的丧失是Heptavax-B常规遭受的两种不同过程的结果。他们还正确地断言，疫苗安全性的最佳证据是，在没有其他风险因素的情况下，没有接种者患上艾滋病。这些数据是可靠的；因此，我对hepavax - b的警惕并非源于对感染艾滋病的恐惧。但是，我必须不同意已经证实从疫苗中实际去除艾滋病病毒的说法。作者使用的杂交程序对每成人剂量Heptavax-B的1 pg病毒核酸水平敏感。使用昵称翻译的9.0千碱基对SacI片段
To the Editor.— I read with great interest the article entitled "The Safety of the Hepatitis B Vaccine." 1 The authors convincingly demonstrated the inactivation of acquired immunodeficiency syndrome (AIDS) virus infectivity and the loss of sedimentable reverse transcriptase activity as a result of two different processes to which Heptavax-B is routinely subjected. They also correctly asserted that the best evidence for the safety of the vaccine is that no recipient has developed AIDS in the absence of other risk factors. These data are sound; hence, my wariness of Heptavax-B does not stem from a fear of acquiring AIDS. I must disagree, however, with the suggestion that physical removal of the AIDS virus from the vaccine has been confirmed. The hybridization procedure used by the authors was sensitive to a level of 1 pg of viral nucleic acid per adult dose of Heptavax-B. Using the nick-translated 9.0-kilobase pair SacI fragment