REACTIVE MICROGLIA ARE POSITIVE FOR HLA-DR IN THE SUBSTANTIA NIGRA OF PARKINSONS AND ALZHEIMERS-DISEASE BRAINS
REACTIVE MICROGLIA ARE POSITIVE FOR HLA-DR IN THE SUBSTANTIA NIGRA OF PARKINSONS AND ALZHEIMERS-DISEASE BRAINS
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DOI：
10.1212/wnl.38.8.1285
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发表时间：
1988-08-01
期刊：
影响因子：
9.9
通讯作者：
MCGEER, EG
中科院分区：
文献类型：
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作者：
MCGEER, PL;ITAGAKI, S;MCGEER, EG
我们检测到大量的HLA-DR阳性反应性小胶质细胞（巨噬细胞），沿着路易体和游离黑色素，在帕金森病（5）和帕金森痴呆症（PD）（5）的所有研究病例的黑质中。我们发现类似的，但不太广泛，病理学在黑质的9例阿尔茨海默型痴呆症（DAT），但在11个年龄匹配的非神经系统的情况下，只有一个。所有死亡前诊断为DAT或PD的痴呆病例均显示海马中大量HLA-DR阳性反应性小胶质细胞和显著的斑块和缠结计数，以及皮质胆碱乙酰转移酶活性降低。11名非痴呆对照中有一名表现出类似皮质病理学的轻度证据。这些数据表明HLA-DR阳性反应性小胶质细胞是神经病理活动的敏感指标。他们建议在老年患者中DAT和帕金森型病理学经常共存。
We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the substantia nigra of all cases studied with Parkinson''s disease (5) and parkinsonism with dementia (PD) (5). We found similar, but less extensive, pathology in the substantia nigra of six of nine cases of dementia of the Alzheimer type (DAT) but in only one of 11 age-matched nonneurologic cases. All dementia cases with a premortem diagnosis of DAT or PD showed large numbers of HLA-DR-positive reactive microglia and significant plaque and tangle counts in the hippocampus, as well as reduced cortical choline acetyltransferase activity. One of 11 nondemented controls showed mild evidence of similar cortical pathology. These data indicate that HLA-DR-positive reactive microglia are a sensitive index of neuropathologic activity. They suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.