Alterations in dopaminergic receptors in Huntington's disease.
Alterations in dopaminergic receptors in Huntington's disease.
复制标题
亨廷顿病中多巴胺能受体的改变。
DOI：
10.1016/0024-3205(77)90111-4
复制
发表时间：
1977
期刊：
影响因子：
6.1
通讯作者：
Henry I. Yamamura
中科院分区：
文献类型：
--
作者：
T. Reisine;J. Fields;Lawrence Z. Stern;Peter C. Johnson;Edward D. Bird;Henry I. Yamamura
为检测死后亨廷顿病脑区多巴胺能受体和胆碱能活动的变化，进行了~3H-螺环丙烷结合试验和胆碱乙酰转移酶(CHAC)活性测定。在舞蹈脑的尾状核、壳核和额叶皮质，~3H-螺哌啶的结合显著减少，这似乎是由于~3H-螺哌醇与多巴胺能受体的结合部位减少，而不是由于~3H-螺哌醇与多巴胺能受体亲和力的降低。在舞蹈症患者的大脑中，尾状核和壳核中的Chac活性也显著降低。新纹状体的~3H-螺哌利多结合率和CHAC活性均降低，提示多巴胺能受体定位于突触后胆碱能中间神经元。基底节多巴胺能受体的改变可能是HD运动异常的原因之一，而额叶皮质的这些受体的改变可能与舞蹈性脑区的神经元变性有关。
To detect variations in dopaminergic receptors and cholinergic activity in regions of postmortem Huntington's diseased brains,3H-spiroperidol binding assays and choline acetyltransferase (ChAc) activities were carried out. A significant reduction in3H-spiroperidol binding in the caudate nucleus, putamen and frontal cortex of choreic brains was detected which appeared to be due to a decrease in the total number of binding sites rather than to a decrease in affinity of3H-spiroperidol for the dopaminergic receptor. In choreic brains, there were also significant reductions in ChAc activity in the caudate nucleus and putamen. The decreases of both3H-spiroperidol binding and ChAc activity in the neostriatum suggest that the dopaminergic receptors are localized postsynaptically on cholinergic interneurons. Dopaminergic receptor alterations in the basal ganglia may be one of the causes of the abnormal motor movements found in HD while alterations of these receptors in the frontal cortex may be associated with the neuronal degeneration found in that area of choreic brains.