Nano-Therapeutics for the Lung: State-of-the-Art and Future Perspectives.
Nano-Therapeutics for the Lung: State-of-the-Art and Future Perspectives.
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DOI：
10.2174/1381612821666150923095742
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发表时间：
2015
影响因子：
3.1
通讯作者：
Nguyen KT
中科院分区：
文献类型：
--
作者：
Iyer R;Hsia CC;Nguyen KT
雾化化合物的吸入是用于将治疗分子靶向递送至肺的流行的非侵入性途径。各种类型的纳米颗粒已被用作载体以促进药物摄取和细胞内作用，从而治疗肺部疾病和/或促进肺修复和生长。这些包括聚合物纳米颗粒、脂质体和树枝状聚合物等。此外，纳米颗粒有时与小分子、细胞因子、生长因子和/或多能干细胞联合使用。在这里，我们审查的基本原理和国家的最先进的纳米技术肺部给药，特别注意新的技术发展和方法，以及与它们相关的挑战，新兴的进步，并在这一领域的未来发展的机会。
Inhalation of aerosolized compounds is a popular, non-invasive route for the targeted delivery of therapeutic molecules to the lung. Various types of nanoparticles have been used as carriers to facilitate drug uptake and intracellular action in order to treat lung diseases and/or to facilitate lung repair and growth. These include polymeric nanoparticles, liposomes, and dendrimers, among many others. In addition, nanoparticles are sometimes used in combination with small molecules, cytokines, growth factors, and/or pluripotent stem cells. Here we review the rationale and state-of-the-art nanotechnology for pulmonary drug delivery, with particular attention to new technological developments and approaches as well as the challenges associated with them, the emerging advances, and opportunities for future development in this field.