Ontogeny of ionotropic glutamate receptor expression in human fetal brain
Ontogeny of ionotropic glutamate receptor expression in human fetal brain
复制标题
DOI：
10.1016/s0165-3806(01)00126-2
复制
发表时间：
2001-04-30
期刊：
影响因子：
--
通讯作者：
Meador-Woodruff, JH
中科院分区：
文献类型：
--
作者：
Ritter, LM;Unis, AS;Meador-Woodruff, JH
谷氨酸受体在中枢神经系统中具有多种作用。最近的证据表明，离子型谷氨酸受体在脑发育，特别是皮质生成，神经元迁移过程中至关重要。和突触发生。在这项研究中，我们研究了亚基mRNA的表达和结合位点的NMDA，AMPA，红藻氨酸受体从孕8 - 20周的人胎脑。在这些大脑中的几个时期，谷氨酸受体的表达很高。每个NMDA，AMPA和红藻氨酸受体亚基转录本的表达水平不同，在发展过程中，与更大的丰度NR1，NR2B，NR2D，GluR7，和KA1 mRNA在大多数胎龄。NMDA，AMPA和红藻氨酸受体的结合位点都被检测到，但每个都有一个独特的表达模式。这些结果表明，谷氨酸受体在人脑发育的早期表达，并随着时间的推移发生复杂的变化，与它们在正常发育中的作用一致。(C)2001 Elsevier Science B.V.保留所有权利。
Glutamate receptors have multiple roles in the central nervous system. Recent evidence suggests that the iontropic glutamate receptors are critical during brain development, particularly fur corticogenesis, neuronal migration. and synaptogenesis. In this study, we examined subunit mRNA expression and binding sites of the NMDA, AMPA, and kainate receptors from gestational weeks 8-20 in human fetal brain. Expression of glutamate receptors was high during several periods in these brains. Different levels of expression of each NMDA, AMPA, and kainate receptor subunit transcripts were present during development, with a greater abundance of NR1, NR2B, NR2D, GluR7, and KA1 mRNA at most gestational ages. Binding sites for NMDA, AMPA, and kainate receptors were all detected, but each had a unique pattern of expression. These results demonstrate that glutamate receptors are expressed early in human brain development, and undergo complex changes over time consistent with their role in normal development. (C) 2001 Elsevier Science B.V. All rights reserved.