EPSTEIN-BARR-VIRUS, CYTOMEGALOVIRUS, AND OTHER VIRAL-INFECTIONS IN CHILDREN AFTER LIVER-TRANSPLANTATION
EPSTEIN-BARR-VIRUS, CYTOMEGALOVIRUS, AND OTHER VIRAL-INFECTIONS IN CHILDREN AFTER LIVER-TRANSPLANTATION
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DOI：
10.1093/infdis/156.2.273
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发表时间：
1987-08-01
影响因子：
6.4
通讯作者：
HO, M
中科院分区：
文献类型：
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作者：
BREINIG, MK;ZITELLI, B;HO, M
我们研究了51名连续的儿科患者肝移植后病毒感染的频率和发病率。初次(67%)和再激活(48%)EB病毒(EBV)感染和再激活(88%)巨细胞病毒(CMV)感染的发生率与成人移植受者相似。然而，儿童移植受者发生原发CMV感染的人数少于成人(P<；.01)。13例巨细胞病毒感染中有5例(38%)有症状，包括肝炎、肺炎、肠炎和单核细胞增多症。初次感染EBV的14名患者中有两名在初次感染后两个月和两年后发展为EBV相关淋巴增殖性综合征，10名再次感染EBV的患者中有一名发展为可能与EBV相关的发热性脑病。其他导致这些儿童感染的病毒包括单纯疱疹病毒、水痘带状疱疹病毒、腺病毒、副流感病毒、呼吸道合胞病毒和轮状病毒。
We studied 51 consecutive pediatric patients for the frequency and morbidity of viral infections after liver transplantation. The incidence of primary (67%) and reactivation (48%) Epstein-Barr virus (EBV) infections and reactivation (88%) cytomegalovirus (CMV) infection was comparable to that seen in adult transplant recipients. However, fewer pediatric than adult transplant recipients experienced primary CMV infection (P < .01). Five (38%) of 13 CMV infections were symptomatic and included hepatitis, pneumonitis, enteritis, and mononucleosis. Two of 14 patients with primary EBV infection subsequently developed, at two months and two years after initial infection, an EBV-associated lymphoproliferative syndrome, and one of 10 patients with reactivated EBV infection developed a possibly EBV-associated febrile encephalopathy. Other viruses causing infection in these children included herpes simplex virus, varicella-zoster virus, adenovirus, parainfluenza virus, respiratory syncytial virus, and rotavirus.