Evolutionary codependency: insights into the mitonuclear interaction landscape from experimental and wild Caenorhabditis nematodes
Evolutionary codependency: insights into the mitonuclear interaction landscape from experimental and wild Caenorhabditis nematodes
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DOI：
10.1016/j.gde.2023.102081
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发表时间：
2023-07-06
影响因子：
4
通讯作者：
Bergthorsson，Ulfar
中科院分区：
文献类型：
--
作者：
Estes，Suzanne;Dietz，Zachary P.;Bergthorsson，Ulfar
亮点Caenorhabditis 是线粒体核协同进化研究的多功能模型。线虫线粒体 DNA 突变谱可能反映 DNA 氧化损伤。线粒体 DNA 缺失在野生分离株中分离，并且很容易在实验室中发生。核编码机制促进线粒体 DNA 缺失的扩展。线粒体基因组可能是快速适应的一个未被充分认识的来源。在新技术的帮助下，相关研究的兴起 过去 15 年的线粒体基因组生物学研究表明，我们误解了，甚至可能大大低估了我们长期共生伙伴的持续生物学和进化意义。虽然我们已经开始触及几个主题的表面，但有关线粒体基因组突变和选择的本质及其与核基因组关系的本质的许多问题仍未得到解答。尽管线虫因其对发育和衰老生物学研究的贡献而闻名，但它越来越被认为是促进对这些领域的理解的优秀模型系统。我们回顾了与线粒体核协同进化和冲突相关的最新发现，并为未来的工作提供了几个肥沃的领域。
HighlightsCaenorhabditis are versatile models for mitonuclear coevolution research.C. elegans mitochondrial DNA mutation spectra may reflect oxidative DNA damage.Mitochondrial DNA deletions segregate in wild isolates and readily occur in the lab.Nuclear-encoded mechanisms promote expansion of mitochondrial DNA deletions.Mitochondrial genomes may be an underappreciated source of rapid adaptation.Aided by new technologies, the upsurgence of research into mitochondrial genome biology during the past 15 years suggests that we have misunderstood, and perhaps dramatically underestimated, the ongoing biological and evolutionary significance of our long-time symbiotic partner. While we have begun to scratch the surface of several topics, many questions regarding the nature of mutation and selection in the mitochondrial genome, and the nature of its relationship to the nuclear genome, remain unanswered. Although best known for their contributions to studies of developmental and aging biology, Caenorhabditis nematodes are increasingly recognized as excellent model systems to advance understanding in these areas. We review recent discoveries with relevance to mitonuclear coevolution and conflict and offer several fertile areas for future work.