Cloning and characterization of a novel human transcription factor AP-2β like gene (TFAP2BL1)
Cloning and characterization of a novel human transcription factor AP-2β like gene (TFAP2BL1)
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DOI：
10.1016/s1357-2725(01)00098-x
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发表时间：
2002-01-01
影响因子：
4
通讯作者：
Mao, YM
中科院分区：
文献类型：
--
作者：
Cheng, C;Ying, K;Mao, YM
AP-2转录因子在发育、形态发生、细胞凋亡、细胞周期调控中起重要作用，并与乳腺肿瘤发生有关。本文报道了一个新的人类转录因子AP-2样基因（TFAP 2BL 1）的克隆和鉴定。其位于人类染色体6p12.1-21.1上。TFAP 2BL 1 cDNA全长2076 bp，编码452个氨基酸，与人Ap-2蛋白相关。TFAP 2BL 1基因与人、小鼠、鸡、羊、果蝇、C. elegans的氨基酸水平。RT-PCR分析表明，该基因在成年胸腺、前列腺、小肠、骨骼肌、胎盘、脑和睾丸组织中有较高的表达水平。(C)2001爱思唯尔科技有限公司版权所有。
The AP-2 transcription factor has been shown to play an important role in development, morphogenesis, apoptosis, cell-cycle control and has also been implicated in mammary oncogenesis. Here we report the cloning and characterization of a novel human transcription factor AP-2 like gene (TFAP2BL1). which is located on human chromosome 6p12.1-21.1. The TFAP2BL1 cDNA is 2076 base pairs in length, encoding a 452-amino acid polypeptide related to human Ap-2protein. TFAP2BL1 gene has significantly high homology to transcription factor AP-2 gene of human, mouse, chicken, sheep, fruit fly, and C. elegans at amino acid level. RT-PCR analysis shows its relatively high expression level in adult thymus, prostate, small intestine, skeletal muscle, placenta, brain, and testis tissues. (C) 2001 Elsevier Science Ltd. All rights reserved.