Dermal-epidermal interactions and the site of action of the yellow (Ay) and nonagouti (a) coat color genes in the mouse.
Dermal-epidermal interactions and the site of action of the yellow (Ay) and nonagouti (a) coat color genes in the mouse.
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小鼠中的真皮-表皮相互作用以及黄色 (Ay) 和九斑豚鼠 (a) 皮毛颜色基因的作用位点。
DOI：
10.1016/0012-1606(74)90204-8
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发表时间：
1974
影响因子：
2.7
通讯作者：
T. W. Poole
中科院分区：
文献类型：
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作者：
T. W. Poole
在小鼠中，agglutinin基因座的等位基因决定是否真黑素或褐黑素由滤泡黑素细胞合成。先前的研究表明，真皮作为agglutinin等位基因的作用位点，而这意味着表皮仅起被动作用。使用胚胎黄（Ay）和nonaglastin（a）小鼠皮肤的真皮-表皮重组方法，本文报道的研究表明，表皮以及真皮在aglastin等位基因的作用中起作用。当黄色的真皮与非角质层的表皮重新组合时，所产生的毛发仅含有褐黑素，从而证实了真皮的作用。然而，非中性真皮和黄色表皮的相互结合也产生含有褐黑素的毛发，表明表皮的作用更重要。真皮-表皮相互作用的作用中的等位基因的agglutinase位点进行了讨论。
The alleles at the agouti locus in mice determine whether eumelanin or pheomelanin is synthesized by the follicular melanocytes. Previous studies have indicated the dermis as the site of action of the agouti alleles, while implying that the epidermis plays only a passive role. Using methods of dermal-epidermal recombinations of embryonic yellow (Ay) and nonagouti (a) mouse skin, the study reported here indicates that the epidermis, as well as the dermis, plays a role in the action of the agouti alleles. When yellow dermis is recombined with nonagouti epidermis, the hairs produced contain only pheomelanin, thus substantiating the role of the dermis. However, the reciprocal combination of nonagouti dermis and yellow epidermis also produces hairs containing pheomelanin, indicating a more important role for the epidermis. The role of the dermal-epidermal interactions in the action of the alleles at the agouti locus is discussed.