Abnormal pontine activation in pathological laughing as shown by functional magnetic resonance imaging
Abnormal pontine activation in pathological laughing as shown by functional magnetic resonance imaging
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DOI：
10.1136/jnnp.2005.073288
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发表时间：
2006-12-01
影响因子：
11
通讯作者：
Wada, Y.
中科院分区：
文献类型：
--
作者：
Kosaka, H.;Omata, N.;Wada, Y.
为探讨病理性笑的病因，对1例65岁的病理性笑患者进行药物治疗前后的3-T功能磁共振成像（fMRI）检查。在这里，我们报告了患者在治疗前的三个任务中始终表现出夸大的脑桥激活，而在使用选择性5 -羟色胺再摄取抑制剂帕罗西汀成功治疗后，脑桥激活不再异常。我们对病理性笑的第一次功能性磁共振成像研究表明，血清素能替代可以减少脑桥神经回路中的异常活动。
To explore the aetiology of pathological laughing, a 65-year-old woman with pathological laughing was examined by 3-T functional magnetic resonance imaging (fMRI) before and after treatment with drugs. Here, we report that the patient consistently showed exaggerated pontine activation during the performance of three tasks before treatment, whereas abnormal pontine activation was no longer found after successful treatment with the selective serotonin reuptake inhibitor, paroxetine. Our findings in this first fMRI study of pathological laughing suggest that serotonergic replacement decreases the aberrant activity in a circuit that involves the pons.