CYTOLETHAL DISTENDING TOXIN (CDT): GENETIC DIVERSITY, STRUCTURE AND ROLE IN DIARRHEAL DISEASE
CYTOLETHAL DISTENDING TOXIN (CDT): GENETIC DIVERSITY, STRUCTURE AND ROLE IN DIARRHEAL DISEASE
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DOI：
10.1080/15569540500320938
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发表时间：
2006-01
期刊：
影响因子：
3.1
通讯作者：
S. Yamasaki;M. Asakura;T. Tsukamoto;S. Faruque;R. Deb;T. Ramamurthy
中科院分区：
文献类型：
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作者：
S. Yamasaki;M. Asakura;T. Tsukamoto;S. Faruque;R. Deb;T. Ramamurthy
1987年，约翰逊和利奥尔发现细胞致死性膨胀毒素（cytolethal expanding toxin，CDT）是由大肠杆菌产生的一种新的蛋白毒素，它不同于产肠毒素大肠杆菌产生的不耐热肠毒素（heat-labile enterotoxin，LT）。杆菌虽然LT仅引起细胞伸长，但CDT引起细胞伸长、细胞膨胀、不可逆的细胞周期停滞，并因此导致培养的哺乳动物细胞死亡。最近，CDT被认为是一个新的细菌毒素家族，作为一种遗传毒素，由一组不同的革兰氏阴性菌产生，所有这些都与粘膜感染有关。尽管人们对CDT的结构和作用方式进行了大量研究，但其在细菌致病中的作用仍不清楚。本文主要对肠道细菌产生的CDT进行了综述，介绍了CDT的历史、基因和蛋白质结构、结构与功能的关系及其作用机制，特别是CDT与胃肠道感染的关系。
In 1987, cytolethal distending toxin (CDT) was discovered by Johnson and Lior as a new type of protein toxin produced by certain strains of Escherichia coli, which is different from heat-labile enterotoxin (LT) produced by enterotoxigenic E. coli. Although LT causes only cell elongation, CDT causes cell elongation, cell distention, irreversible cell cycle arrest, and consequently, death of the cultured mammalian cells. Recently, CDT was recognized as a new family of bacterial toxin, as a genotoxin, produced by a diverse group of gram-negative bacteria, all of which are related to mucosal infection. Although tremendous efforts have been made to study the structure and mode of action of CDT, its role in bacterial pathogenesis still remains unclear. In this review, we focus mainly on CDT produced by enteric bacteria and describe the history of CDT, their gene and protein structure, structure-function relationship, and its mode of action particularly how CDT contributes to the gastrointestinal infections.