Reduction of Cerebral and Corpus Callosum Volumes in Childhood-Onset Systemic Lupus Erythematosus: A Volumetric Magnetic Resonance Imaging Analysis
Reduction of Cerebral and Corpus Callosum Volumes in Childhood-Onset Systemic Lupus Erythematosus: A Volumetric Magnetic Resonance Imaging Analysis
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DOI：
10.1002/art.39680
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发表时间：
2016-09-01
影响因子：
13.3
通讯作者：
Appenzeller, Simone
中科院分区：
文献类型：
--
作者：
Lapa, Aline Tamires;Postal, Mariana;Appenzeller, Simone
目标。很少有研究使用磁共振成像（MRI）体积测量来评估儿童期发病的系统性红斑狼疮（SLE）脑萎缩的患病率。本研究旨在确定儿童期SLE患者大脑和胼胝体萎缩的患病率，并确定萎缩与该疾病的临床、实验室和治疗特征之间可能存在的关系。我们纳入了76例儿童期SLE患者（69例女性和7例男性，中位年龄16岁）和66例年龄和性别匹配的健康对照。根据美国风湿病学会（ACR）标准分析神经系统表现。进一步评估SLE患者的临床和实验室表现、疾病活动性（使用SLE疾病活动性指数）、损害（使用系统性狼疮国际合作诊所/ACR损害指数）以及当前和累积药物暴露。采用Philips 3.0T MRI扫描仪，采用标准化方案进行扫描。儿童期发病SLE患者的大脑和胼胝体体积明显小于对照组(大脑中位体积1,067.9 cm(3)比1,172.7 cm(3)，胼胝体中位体积11.6 cm(3)比13.7 cm(3)；P
Objective. There have been few studies in which the prevalence of cerebral atrophy in childhood-onset systemic lupus erythematosus (SLE) was evaluated using magnetic resonance imaging (MRI) volumetric measurements. This study was undertaken to determine the prevalence of cerebral and corpus callosum atrophy in childhood-onset SLE and to determine the possible relationships between atrophy and clinical, laboratory, and treatment features of the disease.Methods. We included 76 patients with childhood-onset SLE (69 female and 7 male; median age 16 years) and 66 age- and sex-matched healthy controls. Neurologic manifestations were analyzed according to the American College of Rheumatology (ACR) criteria. These SLE patients were further assessed for clinical and laboratory manifestations of SLE, disease activity (using the SLE Disease Activity Index), damage (using the Systemic Lupus International Collaborating Clinics/ACR Damage Index), and current and cumulative drug exposures. Scans were performed with a Philips 3.0T MRI scanner using a standardized protocol.Results. Childhood-onset SLE patients had significantly smaller cerebral and corpus callosum volumes than controls (median cerebral volume 1,067.9 cm(3) versus 1,172.7 cm(3) and median corpus callosum volume 11.6 cm(3) versus 13.7 cm(3); P