Zinc Deficiency Affects DNA Damage, Oxidative Stress, Antioxidant Defenses, and DNA Repair in Rats
Zinc Deficiency Affects DNA Damage, Oxidative Stress, Antioxidant Defenses, and DNA Repair in Rats
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DOI：
10.3945/jn.109.106369
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发表时间：
2009-09-01
影响因子：
4.2
通讯作者：
Ho, Emily
中科院分区：
文献类型：
--
作者：
Song, Yang;Leonard, Scott W.;Ho, Emily
大约12%的美国人没有达到锌的估计平均需要量，可能有边缘性缺锌的风险。锌是参与防御氧化应激和DNA损伤修复的许多蛋白质的重要组成部分。体外研究表明，锌缺乏会导致DNA损伤。我们假设体内锌缺乏通过增加氧化应激和损伤DNA修复导致DNA损伤。Sprague-Dawley大鼠分别饲喂锌充足（ZA; 30 mg Zn/kg）和严重缺锌(ZD；
Approximately 12% of Americans do not consume the Estimated Average Requirement for zinc and could be at risk for marginal zinc deficiency. Zinc is an essential component of numerous proteins involved in the defense against oxidative stress and DNA damage repair. Studies in vitro have shown that zinc depletion causes DNA damage. We hypothesized that zinc deficiency in vivo causes DNA damage through increases in oxidative stress and impairments in DNA repair. Sprague-Dawley rats were fed zinc-adequate (ZA; 30 mg Zn/kg) or severely zinc-deficient (ZD;