Functional roles of phenylalanine(7) of thymic humoral factor-gamma 2 in the impaired blastogenic response of uremic T-lymphocytes.
Functional roles of phenylalanine(7) of thymic humoral factor-gamma 2 in the impaired blastogenic response of uremic T-lymphocytes.
复制标题
胸腺体液因子-γ 2 苯丙氨酸 (7) 在尿毒症 T 淋巴细胞胚细胞生成反应受损中的功能作用。
DOI：
10.3109/03639049809085660
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发表时间：
1998
影响因子：
3.4
通讯作者：
Hiroshi Sekino
中科院分区：
文献类型：
--
作者：
T. Abiko;Hiroshi Sekino
用固相法合成了胸腺体液因子-γ2(THF-γ2)的多肽类似物，其中第7位的苯丙氨酸残基被苯甘氨酸(PHG)、高苯丙氨酸(HPH)和1-萘丙氨酸(1-NAL)取代，并比较了该位芳香族氨基酸的免疫学意义。检测合成肽对尿毒症患者T淋巴细胞植物血凝素(PHA)受损反应的体外恢复作用。这些多肽的活性顺序为(1-NaL7)胸腺体液因子[THF]-Gamma 2&Gt；4-氟(Phe7)THF-Gamma 2&Gt；THF-Gamma 2。而另外两个类似物[Phg7]THF-Gamma 2和[Hph7]THF-Gamma 2在较高浓度下也没有恢复作用。
The peptide analogs of thymic humoral factor-gamma 2 (THF-gamma 2) in which phenylalanine residue at the 7th position are replaced by phenylglycine (Phg), homophenylalanine (Hph), and 1-naphthylalanine (1-Nal) were synthesized by a solid-phase method and the immunological significance of the aromatic amino acid of this position was comparatively investigated. The in vitro restoring effect of the synthetic peptides on the impaired phytohemagglutinin (PHA) response of T-lymphocytes from uremic patients was tested. The observed activities of these peptides were in order (1-Nal7) thymic humoral factor [THF]-gamma 2 > 4-Fluoro (Phe7) THF-gamma 2 > THF-gamma 2. However, the other two analogs, [Phg7] THF-gamma 2 and [Hph7] THF-gamma 2, had no restoring effect even at a higher concentration.