Reproductive Performance in Diabetes Mice with a Special Reference to Uterine Natural Killer Cells and Placental Growth Factor
Reproductive Performance in Diabetes Mice with a Special Reference to Uterine Natural Killer Cells and Placental Growth Factor
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DOI：
10.1292/jvms.71.519
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发表时间：
2009-04-01
影响因子：
1.2
通讯作者：
Kiso, Yasuo
中科院分区：
文献类型：
--
作者：
Phichitrasilp, Thanmaporn;Hondo, Eiichi;Kiso, Yasuo
为了确定糖尿病对生殖性能的影响，本研究采用两种糖尿病小鼠，即KK/TaJcl型2型糖尿病小鼠和链脲佐菌素诱导型1型糖尿病小鼠。特别关注子宫自然杀伤细胞（LINK）和胎盘生长因子（PIGF）。与对照组相比，两种糖尿病小鼠的胎儿数量、胎儿和胎盘重量均显著减少。令人惊讶的是，即使在怀孕期间，两种糖尿病小鼠的LINK细胞仍然存在于子宫腺中。虽然两种糖尿病小鼠的PlGF表达均显著降低，但PlGF蛋白未发生变化。这些结果表明，糖尿病会影响生殖性能，尤其是LINK细胞的行为，但不会影响PlGF的产生。
To determine the effect of diabetes on reproductive performance, two kinds of diabetes mice, i.e., KK/TaJcl mice with Type-II diabetes and Streptozotocin-induced diabetes mice with Type-I diabetes, were used in this study. Particular attention was paid to uterine natural killer (LINK) cells and placental growth factor (PIGF). The number of fetuses, the fetal and placental weights in both diabetes mice were significantly decreased when compared to controls. Surprisingly, LINK cells in both diabetes mice persisted in the metrial gland even at the term of pregnancy. Although PlGF expression in both diabetes mice was significantly decreased, PlGF protein did not change. These results show that diabetes condition affects reproductive performance, particularly LINK cell behavior, but not PlGF production.