Phase behaviour, microstructure and ibuprofen solubilization capacity of pseudo-ternary nonionic microemulsions
Phase behaviour, microstructure and ibuprofen solubilization capacity of pseudo-ternary nonionic microemulsions
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DOI：
10.1016/j.molliq.2011.02.010
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发表时间：
2011-05-01
影响因子：
6
通讯作者：
Jockovic, Jelena
中科院分区：
文献类型：
--
作者：
Djekic, Ljiljana;Primorac, Marija;Jockovic, Jelena
本文研究了拟三元表面活性剂/助表面活性剂/肉豆蔻酸异丙酯/水体系的相行为、微观结构和增溶能力，该体系采用非离子表面活性剂的复杂混合物形成单相微乳液。表面活性剂是PEG-8辛酸/癸酸甘油酯（Labrasol（R））。评价了辛苯聚醇-12和聚山梨酯20和/或PEG-40氢化蓖麻油的明确混合物作为助表面活性剂，所述混合物分别作为市售非离子表面活性剂Solubilisant gamma（R）2421、Solubilisant gamma（R）2429和Cremophor（R）RH 40获得。将表面活性剂+助表面活性剂混合物作为单一组分（假组分）处理，因为表面活性剂与助表面活性剂的重量比（Km 50：50）在整个研究中是恒定的。相行为的研究表明，扩大的单相微乳液面积的表面活性剂+助表面活性剂与油的重量比（SCoS/O）的增加。在SCoS/O为90：10时，在W-max >= 80%w/w的表面活性剂/助表面活性剂/油预浓缩物中形成含有最大水掺入量的完全可稀释的微乳液。采用偏光显微镜、光子相关光谱（PCS）和流变学方法对不同助表面活性剂存在下沿着SCoS/O为90：10的单相微乳液进行了表征。非离子表面活性剂复配体系稳定单相微乳液的性能仅在高度稀释的水包油型微乳液体系中表现出不同的特点。对难溶性药物布洛芬的增溶能力的研究表明，水与表面活性剂+助表面活性剂的比例和油在界面处的渗透至关重要。(C)2011爱思唯尔有限公司版权所有。
This study investigated phase behaviour, microstructure and solubilization capacity of pseudo-ternary surfactant/cosurfactant/isopropyl myristate/water systems employing complex mixtures of nonionic surfactants for formation of single-phase microemulsions. The surfactant was PEG-8 caprylic/capric glycerides (Labrasol (R)). A well defined mixture of octoxynol-12 and polysorbate 20 and/or PEG-40 hydrogenated castor oil, available as commercial nonionicsurfactants Solubilisant gamma (R) 2421, Solubilisant gamma (R) 2429 and Cremophor (R) RH 40, respectively, were evaluated as cosurfactants. Surfactant + cosurfactant mixtures were treated as a single component (pseudo-component), since a surfactant-to-cosurfactant weight ratio (Km 50:50) was constant through the study. Phase behaviour study revealed enlargement of single-phase microemulsion area as surfactant + cosurfactant-to-oil weight ratio (SCoS/O) increases. The formation of fully dilutable microemulsions containing the maximum of water incorporation in the surfactant/cosurfactant/oil preconcentrates of W-max >= 80% w/w, was achieved at SCoS/O 90:10. Microemulsions formed along the single-phase sequence at SCoS/O 90:10 in the presence of different cosurfactants, were characterized using polarized light microscopy, photon correlation spectroscopy (PCS), and rheological measurements. Different performances of complex mixtures of nonionic surfactants in stabilization of single-phase microemulsions were observed only in highly diluted oil-in-water microemulsions area. Investigation of solubilization capacity for poorly soluble drug ibuprofen revealed the critical importance of water-to-surfactant + cosurfactant ratio and penetration of oil at the interface. (C) 2011 Elsevier B.V. All rights reserved.