Correlation between hand bone mineral density and joint destruction in established rheumatoid arthritis
Correlation between hand bone mineral density and joint destruction in established rheumatoid arthritis
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DOI：
10.1016/j.jor.2017.07.010
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发表时间：
2017-12-01
影响因子：
1.5
通讯作者：
Momohara, Shigeki
中科院分区：
文献类型：
--
作者：
Mochizuki, Takeshi;Yano, Koichiro;Momohara, Shigeki
目的：研究日本类风湿关节炎（RA）患者的骨矿物质密度（BMD）与手部修正Sharp总分的相关性。方法：我们检查了57例20年以上的RA患者的手。采用双能x线骨密度仪测量全手骨密度。同时，用x线摄影分析了手，估计van der Heijde-modified Sharp总分（vdH-S）。结果：患者均为女性，中位年龄69.7岁，RA病程29.9年。手骨密度与vdH-S的相关系数分别为-0.513 （P < 0.0001）、-0.576 （P < 0.0001）、-0.339 （P < 0.0001）。结论：长期RA患者手部骨密度与vdH-S相关。手部骨密度是手部结构评估的重要指标。此外，我们可能能够根据长期建立的RA的手部骨密度预测手部的vdH-S。(C) 2017 Surendran教授纪念教育基金会。RELX India, Pvt. Ltd.分部Elsevier出版。版权所有。
Objective: We aimed to clarify the correlation between bone mineral density (BMD) and the modified total Sharp score of the hand in Japanese patients with established rheumatoid arthritis (RA).Methods: We examined the hands of 57 patients who had RA for more than 20 years. BMD for the whole hand was measured using dual-energy x-ray absorptiometry. Concurrently, the hands were analyzed using radiography to estimate the van der Heijde-modified total Sharp score (vdH-S).Results: The patients were all women with a median age of 69.7 years and RA disease duration of 29.9 years. The correlation coefficients were -0.513 (P < 0.0001) for hand BMD and vdH-S of the hand, -0.576 (P < 0.0001) for hand BMD and the erosion score of the vdH-S, and -0.339 (P < 0.0001) for hand BMD and the joint narrowing score of the vdH-S.Conclusions: Hand BMD is correlated with the vdH-S in long-established RA. The hand BMD is important for structural assessment of the hand. Additionally, we may be able to predict the vdH-S of the hand on the basis of the hand BMD in long-established RA. (C) 2017 Prof. PK Surendran Memorial Education Foundation. Published by Elsevier, a division of RELX India, Pvt. Ltd. All rights reserved.