The Efficacy of Intravitreal Povidone Iodine Application in Experimental Staphylococcus epidermidis Endophthalmitis
The Efficacy of Intravitreal Povidone Iodine Application in Experimental Staphylococcus epidermidis Endophthalmitis
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DOI：
10.1159/000217721
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发表时间：
2009-01-01
影响因子：
2.1
通讯作者：
Alexiou-Daniel, Styliani
中科院分区：
文献类型：
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作者：
Brozou, Catherine G.;Karabatakis, Vasilios;Alexiou-Daniel, Styliani
目的：本研究旨在评价聚维酮碘（PVI）在幼兔实验性细菌性眼内炎治疗中的作用。方法：选用白色家兔20只。将表皮葡萄球菌的菌落形成单位（CFU）玻璃体内注射到每只动物的右眼中。每天对注射眼进行临床评价（眼前节和后节检查），当出现眼内炎的临床体征时，玻璃体内注射0.1 ml PVI。在第1组（n = 10）中，PVI的注射浓度为0.1%，在第2组（n = 10）中，PVI的注射浓度为0.2%。观察期结束时，进行玻璃体样本培养，并取玻璃体和视网膜标本进行光组织学检查。结果：第1组的眼睛没有表现出任何临床改善的迹象。玻璃体培养显示存在10（8）CFU/ml的S。表皮组织学检查显示急性炎症。第2组动物的炎症明显逐渐消退。营养液培养S.表皮被证明是不育的。组织学检查显示慢性炎症。结论：玻璃体腔内注射0.2%PVI对S.表皮版权所有（C）2009 S. Karger AG，巴塞尔
Aim: The aim of the current study is to evaluate the role of povidone iodine (PVI) in the management of experimental bacterial endophthalmitis in young rabbits. Method: Twenty white rabbits were used. Colony-forming units (CFU) of Staphylococcus epidermidis were injected intravitreally into the right eye of each animal. Injected eyes were evaluated clinically daily (anterior and posterior segment examination), and when clinical signs of endophthalmitis appeared, an injection of 0.1 ml PVI was made intravitreally. In group 1 (n = 10), the injected concentration of PVI was 0.1%, and in group 2 (n = 10) the concentration was 0.2%. At the end of the observation period, vitreous sample culture was made, and vitreous and retina specimens were taken for light histology examination as well. Results: Group 1 eyes did not show any signs of clinical improvement. Vitreous culture showed the presence of 10(8) CFU/ml of S. epidermidis. Histological examination indicated acute inflammation. Group 2 animals presented a clear gradual regression of the inflammation. Vitreous culture for S. epidermidis proved to be sterile. Histological examination indicated chronic inflammation. Conclusions: Intravitreal injection of 0.2% PVI is likely to inhibit bacterial endophthalmitis of rabbit eyes due to S. epidermidis. Copyright (C) 2009 S. Karger AG, Basel