SEPARATION OF IL-4 PRODUCTION FROM TH-CELL PROLIFERATION BY AN ALTERED T-CELL RECEPTOR LIGAND
SEPARATION OF IL-4 PRODUCTION FROM TH-CELL PROLIFERATION BY AN ALTERED T-CELL RECEPTOR LIGAND
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DOI：
10.1126/science.1833816
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发表时间：
1991-05-31
期刊：
影响因子：
56.9
通讯作者：
ALLEN, PM
中科院分区：
文献类型：
--
作者：
EVAVOLD, BD;ALLEN, PM
在抗原呈递细胞的存在下，小鼠血红蛋白（Hb）特异性的T辅助细胞（Th）通过细胞因子（白细胞介素-4）的分泌和增殖对其免疫原肽作出反应。改变的Hb肽与单一氨基酸替换只诱导细胞因子分泌，不诱导增殖。白细胞介素-1共同刺激并使Th增殖反应恢复到正常水平。改变的肽也支持同源T细胞- b细胞相互作用，表明T细胞辅助功能。因此，这一结果表明T细胞受体具有差异信号传导能力。
In the presence of antigen presenting cells, a murine T helper (Th) cell specific for murine hemoglobin (Hb) responded to its immunogenic peptide by both cytokine (interleukin-4) secretion and proliferation. An altered Hb peptide with a single amino acid substitution induced only cytokine secretion and did not induce proliferation. Interleukin-1 costimulated and restored the Th proliferative response to normal levels. The altered peptide also supported cognate T cell-B cell interactions indicative of T cell helper function. Thus, this result suggests that the T cell receptor has the capacity of differential signaling.