Synthesis and biological activities of local anesthetics
Synthesis and biological activities of local anesthetics
复制标题
局麻药的合成及生物活性
作者：
Shiyang Zhou;G. Huang;Guangying Chen
局麻药主要用于口腔科、眼科、妇科和外科，暂时缓解疼痛。局部麻醉剂作用于神经末梢或神经干周围，并与神经膜上的特定钠离子（Na+）通道位点结合。它们可以通过减少Na+通过钠离子通道来影响膜电位，从而阻断神经冲动的产生和传导，可逆地阻断感觉神经冲动的产生和传导。局部麻醉剂用于局部外科手术和治疗中以方便。本文主要综述了近年来局部麻醉药的研究进展，并对各种新化合物的设计、合成及生物活性等方面进行了讨论。
Local anesthetics are mainly used in stomatology, ophthalmology, gynecology and surgery to temporarily relieve pain. Local anesthetics act on nerve endings or around nerve trunks, and are combined with specific sodium ion (Na+) channel sites on the nerve membrane. They can affect the membrane potential by reducing Na+ passage through sodium ion channels, thus blocking the generation and conduction of nerve impulses, reversibly blocking the generation and conduction of sensory nerve impulses. Local anesthetics are used for convenience in local surgical operations and treatments. Herein, we mainly review the research progress on local anesthetics and discuss the important aspects of design, synthesis and biological activity of various new compounds.
丁卡因对大鼠心室肌细胞自发钙释放的双重作用。
DOI：
10.1113/jphysiol.1997.sp022021
发表时间：
1997
期刊：
The Journal of physiology
影响因子：
--
作者：
Györke,S;Lukyanenko,V;Györke,I
通讯作者：
Györke,I
影响因子：
--
作者：
W. Catterall
通讯作者：
W. Catterall
影响因子：
20.1
作者：
SHEU, SS;LEDERER, WJ
通讯作者：
LEDERER, WJ