The human parietal operculum. I. Cytoarchitectonic mapping of subdivisions
The human parietal operculum. I. Cytoarchitectonic mapping of subdivisions
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DOI：
10.1093/cercor/bhi105
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发表时间：
2006-02-01
期刊：
影响因子：
3.7
通讯作者：
Amunts, K
中科院分区：
文献类型：
--
作者：
Eickhoff, SB;Schleicher, A;Amunts, K
如术中刺激和功能成像研究所示，人类次级躯体感觉皮质位于顶盖。然而，这个功能定义的区域的解剖学相关性的位置和范围仍然未知。因此，我们使用定量细胞构筑分析，在10个人死后大脑的细胞体染色的组织切片上绘制了推测的大脑皮质解剖相关图。在顶盖测量灰阶指数(GLI)，它是神经细胞体体积分数的指标。垂直于皮质各层提取Gli谱作为皮质的层状结构。通过对椎板轮廓的多变量统计分析，独立于观察者检测细胞构筑边界。确定了四个细胞构造区(称为OP 1-4)。顶盖的这种细胞构筑异质性与人类SII皮质的功能成像研究结果以及来自非人类灵长类动物的数据相一致，其中SII内的多个亚区已被电生理学和连接性研究证实。
The human secondary somatosensory cortex (SII) is located on the parietal operculum, as shown by intraoperative stimulation and functional imaging studies. The position and extent of the anatomical correlates of this functionally defined region, however, are still unknown. We have therefore histologically mapped the putative anatomical correlates of the SII cortex in cell-body-stained histological sections of 10 human postmortem brains using quantitative cytoarchitectonic analysis. The gray level index (GLI), which is an indicator of the volume fraction of nerve cell bodies, was measured in the parietal operculum. GLI profiles as measures of the laminar pattern of the cortex were extracted perpendicular to cortical layers. Cytoarchitectonic borders were detected observer-independently by multivariate statistical analysis of the laminar profiles. Four cytoarchitectonic areas (termed OP 1-4) were identified. This cytoarchitectonic heterogeneity of the parietal operculum corresponds to results of functional imaging studies on the human SII cortex and data from non-human primates where multiple subregions within SII have been demonstrated by electrophysiological and connectivity studies.