Expression of HGF and cMet in the peripheral nervous system of adult rats following sciatic nerve injury
Expression of HGF and cMet in the peripheral nervous system of adult rats following sciatic nerve injury
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DOI：
10.1097/00001756-200105250-00022
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发表时间：
2001-05-25
期刊：
影响因子：
1.7
通讯作者：
Noguchi, K
中科院分区：
文献类型：
--
作者：
Hashimoto, N;Yamanaka, H;Noguchi, K
肝细胞生长因子 (HGF) 对不同类型的神经元（包括运动神经元、感觉神经元和副交感神经元）表现出神经营养特性。我们证明坐骨神经结扎会诱导坐骨神经远端段至结扎部位的 HGF 受体、c-met、mRNA 增加，并导致近端段延迟升高。免疫组织化学分析显示cMet和GFAP共定位，并表明损伤后雪旺细胞在坐骨神经中表达cMet：在脊髓和背根神经节中检测到HGF mRNA，并且神经损伤没有改变表达。这些数据表明，周围神经系统中HGF和cMet的表达显示出神经损伤后独特的调节模式。 NeuroReport 12：1403-1407 (C) 2001 Lippincott Williams & Wilkins。
Hepatocyte growth factor (HGF) exhibits neurotrophic properties on different types of neuron, including motor, sensory and parasympathetic neurons. We demonstrate that sciatic nerve ligation induces an increase of the HGF receptor, c-met, mRNA in the distal segment of the sciatic nerve to the ligation site and a delayed elevation in the proximal segment. Immunohistochemical analysis revealed co-localization of cMet and GFAP and indicates that Schwann cells express cMet in the sciatic nerve after injury: HGF mRNA was detected in the spinal cord and DRG, and nerve injury did not alter the expression. These data demonstrate that the expression of HGF and cMet in the peripheral nervous system shows the unique pattern of regulation following nerve injury. NeuroReport 12:1403-1407 (C) 2001 Lippincott Williams & Wilkins.