The mRNA 5′ cap-binding protein eIF4E and control of cell growth
The mRNA 5′ cap-binding protein eIF4E and control of cell growth
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DOI：
10.1016/s0955-0674(98)80150-6
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发表时间：
1998-04-01
影响因子：
7.5
通讯作者：
Gingras, AC
中科院分区：
文献类型：
--
作者：
Sonenberg, N;Gingras, AC
在翻译水平控制基因表达在细胞生长和增殖中是重要的。最近的工作已经确定了将信号从细胞外刺激传递到几个翻译组件的途径。翻译调控的关键参与者是eIF 4 E，mRNA 5'帽结合蛋白。几种信号通路影响eIF 4 E的活性。本文综述了MAP激酶信号通路导致eIF 4 E磷酸化和调节eIF 4 E功能抑制的通路的最新研究结果。一个主要的未解决的问题是如何在翻译的变化调节细胞生长速率，和工作模型将进行讨论。(C)Current Biology Ltd ISSN 0955-0674。
Control of gene expression at the translational level is important in cell growth and proliferation. Recent work has identified pathways that transmit signals from extracellular stimuli to several translation components. A key participant in regulation of translation is eIF4E, the mRNA 5' cap-binding protein. Several signalling pathways impact on the activity of eIF4E. This review will summarise recent findings on the MAP kinase signalling pathway that leads to phosphorylation of eIF4E and on pathways that regulate repression of eIF4E function. A major unresolved question is how the changes in translation modulate cell growth rate, and a working model will be discussed. (C) Current Biology Ltd ISSN 0955-0674.