Protein-bound uremic toxins: new insight from clinical studies.
Protein-bound uremic toxins: new insight from clinical studies.
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DOI：
10.3390/toxins3070911
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发表时间：
2011-07
期刊：
影响因子：
4.2
通讯作者：
Massy ZA
中科院分区：
文献类型：
--
作者：
Liabeuf S;Drüeke TB;Massy ZA
尿毒症综合征是由于大量化合物的进行性滞留，这些化合物在正常情况下由健康的肾脏排出。当这些化合物与生物功能发生负面相互作用时，它们被称为尿毒症毒素。本综述集中在一类特定的分子，即蛋白结合尿毒症毒素家族。最近的实验研究表明，蛋白结合毒素不仅参与慢性肾脏疾病（CKD）的进展，而且还参与心血管疾病的产生和加重。两种蛋白结合的尿毒症保留溶质，即硫酸吲哚酚和硫酸对甲苯酯，已被证明发挥突出的作用。然而，尽管这两种分子属于同一类分子，但在实验动物中对心血管系统产生毒性作用，并在CKD患者的血清中积累，但它们在心血管疾病和其他并发症方面可能具有不同的临床影响。本综述的主要目的是根据最近的临床研究，评估对甲苯基硫酸盐和硫酸吲哚酚保留对CKD患者结局的影响。
The uremic syndrome is attributed to the progressive retention of a large number of compounds which, under normal conditions, are excreted by healthy kidneys. The compounds are called uremic toxins when they interact negatively with biological functions. The present review focuses on a specific class of molecules, namely the family of protein-bound uremic toxins. Recent experimental studies have shown that protein-bound toxins are involved not only in the progression of chronic kidney disease (CKD), but also in the generation and aggravation of cardiovascular disease. Two protein-bound uremic retention solutes, namely indoxyl sulfate and p-cresyl sulfate, have been shown to play a prominent role. However, although these two molecules belong to the same class of molecules, exert toxic effects on the cardiovascular system in experimental animals, and accumulate in the serum of patients with CKD they may have different clinical impacts in terms of cardiovascular disease and other complications. The principal aim of this review is to evaluate the effect of p-cresyl sulfate and indoxyl sulfate retention on CKD patient outcomes, based on recent clinical studies.
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6.1
作者：
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