Endocannabinoid system and opioid addiction: Behavioural aspects
Endocannabinoid system and opioid addiction: Behavioural aspects
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DOI：
10.1016/j.pbb.2005.01.031
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发表时间：
2005-06-01
影响因子：
3.6
通讯作者：
Fratta, W
中科院分区：
文献类型：
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作者：
Fattore, L;Deiana, S;Fratta, W
大麻素产生的各种药理作用与阿片类药物非常相似。已经提出了与阿片系统的直接和间接相互作用来解释一些大麻素的作用，如镇痛和减轻阿片类戒断综合征，并提供证据支持大麻素和阿片类药物的奖励性质可能在功能上相关的观点。特别是，越来越多的研究指出内源性大麻素系统在阿片类药物奖励和成瘾作用的调节中起着重要作用。目前的审查审查在过去几年中的大麻素类阿片药物滥用和依赖的相互作用的阐明进展，侧重于最近的研究结果，使用不同的成瘾动物模型的行为研究。具体来说，在这里，我们回顾了行为方面的数据（即，药物滥用、依赖性、耐受性、致敏性、复吸和药物脆弱性），特别是内源性大麻素系统在类阿片成瘾中的作用。这些药理学相互作用的潜在生化机制进行了讨论，在阿片类药物依赖的药物治疗可能的治疗意义。然而，个性化的精确的解剖基板和分子机制的这种相互作用仍然是一个复杂的和具有挑战性的领域，为未来的研究。(c)2005爱思唯尔公司All rights reserved.
Cannabinoids produce a variety of pharmacological effects very similar to those elicited by opioids. Direct and indirect interactions with opioid system have been proposed to explain some cannabinoid effects such as analgesia and attenuation of opioid-withdrawal syndrome, and evidence has been provided in support to the notion that rewarding properties of cannabinoids and opioids might be functionally linked. In particular, a growing body of studies points to an important role of the endogenous cannabinoid system in the modulation of opioid rewarding and addictive effects. The current review examines progresses in the past few years in the elucidation of cannabinoid-opioid interactions in drug abuse and dependence, focusing on recent findings from behavioural studies using different animal models of addiction. Specifically, here we review data on the behavioural aspects (i.e., drug abuse, dependence, tolerance, sensitization, relapse and drug vulnerability) of the specific, often reciprocal, cross-talk between cannabinoids and opioids with particular reference to the role of the endocannabinoid system in opioid addiction. The potential biochemical mechanisms involved in these pharmacological interactions are discussed together with possible therapeutic implications in the pharmacotherapy of opioid dependence. However, individuation of the precise anatomical substrates and molecular mechanisms of such interaction still remains a complex and challenging field for future research. (c) 2005 Elsevier Inc. All rights reserved.