HELICOBACTER-PYLORI PHENOTYPES ASSOCIATED WITH PEPTIC-ULCERATION
HELICOBACTER-PYLORI PHENOTYPES ASSOCIATED WITH PEPTIC-ULCERATION
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DOI：
10.3109/00365529409091402
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发表时间：
1994-01-01
影响因子：
1.9
通讯作者：
BLASER, MJ
中科院分区：
文献类型：
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作者：
BLASER, MJ
幽门螺杆菌的持续感染发生在很大比例的人口中，特别是在社会经济地位较低的国家。这种感染几乎总是产生慢性胃炎，尽管在大多数个体中，它在临床上是无症状的，只有少数感染者发展为H。幽门引起的消化性溃疡本文综述了H.幽门螺杆菌菌株至少部分地对观察到的感染结果的变异性负责。迄今为止，四个表型，不同的H。幽门螺杆菌菌株已经被鉴定：脂多糖结构的变异; cagA编码产物的表达;空泡化细胞毒素的产生，以及嗜中性粒细胞的增强的活化。这些表型相互关联，与增强的组织炎症和消化性溃疡有关，提示H。pylori菌株特性对H.幽门感染
Persistent infection with Helicobacter pylori occurs in a large percentage of the population, particularly in countries with low socioeconomic status. Such infection nearly always produces chronic gastric inflammation, although in most individuals it is clinically silent and only a minority of infected persons develop H. pylori-induced peptic ulcers. In this review, the hypothesis that diversity among H. pylori strains is at least partly responsible for the observed variability in the outcome of infection is explored. To date, four phenotypes that vary among H. pylori strains have been identified: variations in lipopolysaccharide structure; expression of the cagA-encoded product; production of a vacuolating cytotoxin, and enhanced activation of neutrophils. These phenotypes are, associated with one another, with enhanced tissue inflammation, and with peptic ulceration, suggesting that H. pylori strain characteristics have an important influence on the clinical outcome of H. pylori infection.