DEVELOPMENTAL ALTERATIONS ASSOCIATED WITH SPONTANEOUS CLEFT-LIP AND PALATE IN CL FR MICE
DEVELOPMENTAL ALTERATIONS ASSOCIATED WITH SPONTANEOUS CLEFT-LIP AND PALATE IN CL FR MICE
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DOI：
10.1002/aja.1001640104
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
JOHNSTON, MC
中科院分区：
文献类型：
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作者：
MILLICOVSKY, G;AMBROSE, LJH;JOHNSTON, MC
Cleft lip with or without associated cleft palate [Cl(P)], one of the most common human malformations, is believed to be caused by a combination of genetic and environmental factors. To study the morphological manifestations of the genetic factors in this interaction, the embryonic development of the CL/Fr mouse strain (with a mean incidence of 36% spontaneous CL(P) in the colony was compared with that of the C57B1/6J mouse strain (with no CL(P) in the colony). Results from a scanning electron microscopic study demonstrated that, when compared with C57B1/6J embryos, CL/Fr embryos have several developmental differences including altered facial geometry, 2) depressed ability of the surface epithelium of primary-palate primordia to participate in the fusion process and variable hypoplasia of the lateral nasal prominences. All of these alterations may contribute to the pathogenesis of CL(P) in the CL/Fr mouse strain.
