Bilirubin Uridine Diphosphate-glucuronosyltransferase Polymorphism as a Risk Factor for Prolonged Hyperbilirubinemia in Japanese Preterm Infants
Bilirubin Uridine Diphosphate-glucuronosyltransferase Polymorphism as a Risk Factor for Prolonged Hyperbilirubinemia in Japanese Preterm Infants
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胆红素-尿苷二磷酸-葡萄糖醛酸转移酶多态性是日本早产儿长期高胆红素血症的危险因素
DOI：
10.1016/j.jpeds.2017.07.014
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发表时间：
2017-11-01
影响因子：
5.1
通讯作者：
Maruo, Yoshihiro
中科院分区：
文献类型：
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作者：
Yanagi, Takahide;Nakahara, Sayuri;Maruo, Yoshihiro
目的探讨胆红素尿苷二磷酸-葡萄糖醛酸转移酶基因（UGT1A1*6）变异是否为早产儿长期高胆红素血症的危险因素。研究设计46名日本早产儿（150 mu mol/L (8.77 mg/dL)） 14天以上的UGT1A1基因型。结果病例组46例患儿中有41例（89.1%）存在多态变异c.211G> a, p.G71R （UGT1A1*6）。对照组38例中有7例（18.4%）存在UGT1A1*6。延长型高胆红素血症组UGT1A1*6等位基因频率为0.641，显著高于对照组（0.092;P < 0.001）。病例组46例婴儿中有39例母乳喂养，对照组仅有10例母乳喂养。结论UGT1A1*6是日本早产儿长期非结合性高胆红素血症的危险因素。鉴于本研究中母乳喂养率的不同，需要更多的数据才能得出明确的结论。
Objective To determine whether a variant of the bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1*6) is a risk factor for prolonged hyperbilirubinemia in preterm infants.Study design UGT1A1 genotypes in 46 Japanese preterm infants (150 mu mol/L (8.77 mg/dL) beyond 14 days of life.Results In the case group, 41 of 46 infants (89.1%) had a polymorphic variant, c.211G>A, p.G71R (UGT1A1*6). In the control group, 7 of 38 (18.4%) had UGT1A1*6. The allele frequency of UGT1A1*6 was 0.641 in the prolonged hyperbilirubinemia group, which was significantly higher than in the control group (0.092; P < .001). In total, 39 of 46 infants in the case group were breast fed, and only 10 infants in the control group were breast fed.Conclusions These data suggest that UGT1A1*6 is a risk factor for prolonged unconjugated hyperbilirubinemia in preterm infants in Japan. Given the different rate of breast feeding in this study, additional data are necessary for drawing a definitive conclusion.