Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam
Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam
复制标题
DOI：
10.2337/diacare.25.10.1790
复制
发表时间：
2002-10-01
期刊：
影响因子：
16.2
通讯作者：
Lee, KE
中科院分区：
文献类型：
--
作者：
Klein, BEK;Klein, R;Lee, KE
目的-为了确定是否代谢综合征的组成部分之前5年的心血管疾病和diabetes.RESEARCH设计和方法的发病率-一个人口年龄在43-84岁的人进行了评估，从1988年至1990年，并再次5年后。在两次检查时，按照相同的方案获得病史、血压和实验室指标。无糖尿病的受试者根据基线时的尿酸水平、高血压、高危血脂水平、高尿酸水平和蛋白尿进行分类。在随访中获得了心肌梗死、心绞痛、中风和糖尿病的病史。结果-在4,423名无糖尿病的受试者中，6.9%的受试者有高水平的甘油三酯，18.4%有高血压，82.7%有高危血脂水平（血清总胆固醇高或HDL胆固醇低或这两个水平的比例高），27%的人尿酸水平升高，33.2%的人BMI高，3.3%有蛋白尿（≥ 30 mg/dl）。5年后，发生心血管疾病的风险随着存在成分的数量而增加;具有一种成分的人中，2.5%患上心血管疾病，而具有四种或四种以上成分的人中，14.9%患上心血管疾病。一个组成部分，糖尿病发展在1.1% 5年后，而糖尿病发展在17.9%的那些有四个或更多的components.CONCLUSIONS -组件的代谢综合征是常见的，并与事件心血管疾病和糖尿病5年后。改变BMI、血脂水平和血压的干预措施可能会减少糖尿病和心血管疾病的发生。
OBJECTIVE - To determine whether components of the metabolic syndrome precede the 5-year incidence of cardiovascular disease and diabetes.RESEARCH DESIGN AND METHODS- A population of individuals aged 43-84 years was evaluated from 1988 to 1990 and again 5 years later. Medical history, blood pressure, and laboratory measures were obtained at both examinations following the same protocols. Subjects without diabetes were classified according to level of glycemia, high blood pressure, high-risk lipid levels, high uric acid levels, and proteinuria at baseline. History of incident myocardial infarction, angina, stroke, and diabetes was obtained at follow-up.RESULTS- Of the 4,423 subjects without diabetes, 6.9% had elevated levels of glycemia, 18.4% had high blood pressure, 82.7% had high-risk lipid levels (either high serum total cholesterol or low HDL cholesterol or high ratio of these two levels), 27% had elevated uric acid levels, 33.2% had high BMI, and 3.3% had proteinuria (greater than or equal to30 mg/dl). The risk of incident cardiovascular disease 5 years later increased with the number of the components present; 2.5% of those with one component developed cardiovascular disease, whereas 14.9% of those with four or more components developed cardiovascular disease. Of those with one component, diabetes developed in 1.1% 5 years later, whereas diabetes developed in 17.9% of those with four or more components.CONCLUSIONS - Components of the metabolic syndrome are common and are associated with incident cardiovascular disease and diabetes after 5 years. Interventions to alter BMI, lipid levels, and blood pressure may decrease incident diabetes and cardiovascular disease.